Chronic repetitive transcranial magnetic stimulation increases hippocampal neurogenesis in rats

被引：97

作者：

Ueyama, Eiko ^{[1
]}

Ukai, Satoshi ^{[1
,2
]}

Ogawa, Asao ^{[2
]}

Yamamoto, Masakiyo ^{[2
]}

Kawaguchi, Shunsuke ^{[2
]}

Ishii, Ryouhei ^{[2
]}

Shinosaki, Kazuhiro ^{[1
]}

机构：

[1] Wakayama Med Univ, Dept Neuropsychiat, Wakayama 6410012, Japan

[2] Osaka Univ, Sch Med, Dept Psychiat, Osaka, Japan

来源：

PSYCHIATRY AND CLINICAL NEUROSCIENCES | 2011年 / 65卷 / 01期

关键词：

depression; hippocampus; neurogenesis; rat; transcranial magnetic stimulation; DEPRESSION; MODEL; TMS;

D O I：

10.1111/j.1440-1819.2010.02170.x

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Aim: While the underlying therapeutic mechanisms of repetitive transcranial magnetic stimulation (rTMS) treatment for depression remain unclear, recent animal studies have suggested that hippocampal neurogenesis might be required for the effects of antidepressant treatments including antidepressant drugs and electroconvulsive therapy. The aim of this study was to examine chronic rTMS effects on hippocampal neurogenesis in rats. Methods: Using a 70-mm figure-of-eight coil, the stimulating parameters were set to 25 Hz and 70% of the rTMS device's maximum power. For 14 consecutive days, bromodeoxyuridine (BrdU) and 1000 pulses of rTMS were administered daily. Cell proliferation in the dentate gyrus was examined with immunohistochemistry. Results: In the rTMS-treated group, BrdU-positive cells were significantly increased in the dentate gyrus. Conclusion: Our results suggest that hippocampal neurogenesis might be involved in the antidepressant effects of chronic rTMS.

引用

页码：77 / 81

页数：5

共 14 条

[11] Effects of different frequencies of transcranial magnetic stimulation (TMS) on the forced swim test model of depression in rats [J].

Sachdev, PS ;

McBride, R ;

Loo, C ;

Mitchell, PM ;

Malhi, GS ;

Croker, V .

BIOLOGICAL PSYCHIATRY, 2002, 51 (06) :474-479

[12] Adult hippocampal neurogenesis in depression [J].

Sahay, Amar ;

Hen, Rene .

NATURE NEUROSCIENCE, 2007, 10 (09) :1110-1115

[13] Requirement of hippocampal neurogenesis for the behavioral effects of antidepressants [J].

Santarelli, L ;

Saxe, M ;

Gross, C ;

Surget, A ;

Battaglia, F ;

Dulawa, S ;

Weisstaub, N ;

Lee, J ;

Duman, R ;

Arancio, O ;

Belzung, C ;

Hen, R .

SCIENCE, 2003, 301 (5634) :805-809

[14] Neurogenesis in the dentate gyrus of the rat following electroconvulsive shock seizures [J].

Scott, BW ;

Wojtowicz, JM ;

Burnham, WM .

EXPERIMENTAL NEUROLOGY, 2000, 165 (02) :231-236

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