Sporolides A and B:: Structurally unprecedented halogenated macrolides from the marine actinomycete Salinispora tropica

被引：108

作者：

Buchanan, GO ^{[1
]}

Williams, PG ^{[1
]}

Feling, RH ^{[1
]}

Kauffman, CA ^{[1
]}

Jensen, PR ^{[1
]}

Fenical, W ^{[1
]}

机构：

[1] Univ Calif San Diego, Scripps Inst Oceanog, Ctr Marine Biotechnol & Biomed, La Jolla, CA 92093 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 13期

关键词：

D O I：

10.1021/ol050901i

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Analysis of the fermentation broth of a strain of the marine actinomycete Salinispora tropica has led to the isolation of two unprecedented macrolides, sporolides A (1) and B (2). The structures and absolute stereochemistries of both metabolites were elucidated using a combination of NMR spectroscopy and X-ray crystallography.

引用

页码：2731 / 2734

页数：4

共 16 条

[1] Bioactive microbial metabolites -: A personal view
Bérdy, J
[J]. JOURNAL OF ANTIBIOTICS, 2005, 58 (01) : 1 - 26
[2] Search and discovery strategies for biotechnology: The paradigm shift
Bull, AT
Ward, AC
Goodfellow, M
[J]. MICROBIOLOGY AND MOLECULAR BIOLOGY REVIEWS, 2000, 64 (03) : 573 - +
[3] Salinosporamide A:: A highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus Salinospora
Feling, RH
Buchanan, GO
Mincer, TJ
Kauffman, CA
Jensen, PR
Fenical, W
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2003, 42 (03) : 355 - +
[4] Better antibiotics through chemistry
Frantz, S
[J]. NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (11) : 900 - 901
[5] Culturable marine actinomycete diversity from tropical Pacific Ocean sediments
Jensen, PR
Gontang, E
Mafnas, C
Mincer, TJ
Fenical, W
[J]. ENVIRONMENTAL MICROBIOLOGY, 2005, 7 (07) : 1039 - 1048
[6] DISTRIBUTION OF ACTINOMYCETES IN NEAR-SHORE TROPICAL MARINE-SEDIMENTS
JENSEN, PR
DWIGHT, R
FENICAL, W
[J]. APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 1991, 57 (04) : 1102 - 1108
[7] The evolving role of natural products in drug discovery
Koehn, FE
Carter, GT
[J]. NATURE REVIEWS DRUG DISCOVERY, 2005, 4 (03) : 206 - 220
[8] Structure-activity relationship studies of salinosporamide a (NPI-0052), a novel marine derived proteasome inhibitor
Macherla, VR
Mitchell, SS
Manam, RR
Reed, KA
Chao, TH
Nicholson, B
Deyanat-Yazdi, G
Mai, B
Jensen, PR
Fenical, WF
Neuteboom, STC
Lam, KS
Palladino, MA
Potts, BCM
[J]. JOURNAL OF MEDICINAL CHEMISTRY, 2005, 48 (11) : 3684 - 3687
[9] Diversity of cultivable actinobacteria in geographically widespread marine sediments
Maldonado, LA
Stach, JEM
Pathom-aree, W
Ward, AC
Bull, AT
Goodfellow, M
[J]. ANTONIE VAN LEEUWENHOEK INTERNATIONAL JOURNAL OF GENERAL AND MOLECULAR MICROBIOLOGY, 2005, 87 (01): : 11 - 18
[10] MALDONADO LA, IN PRESS INT J SYST

← 1 2 →