Kinesin motors and microtubule-based organelle transport in Dictyostelium discoideum

被引：15

作者：

Klopfenstein, DR

Holleran, EA

Vale, RD

机构：

[1] Univ Calif San Francisco, Howard Hughes Med Inst, San Francisco, CA 94107 USA

[2] Univ Calif San Francisco, Dept Mol & Cellular Pharmacol, San Francisco, CA 94107 USA

来源：

JOURNAL OF MUSCLE RESEARCH AND CELL MOTILITY | 2002年 / 23卷 / 7-8期

关键词：

D O I：

10.1023/A:1024403006680

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Movement of membrane cargoes and chromosomes is driven by kinesin and dynein motors in most eukaryotic cells. In this review, we describe the known kinesin and dynein genes in Dictyostelium. Dictyostelium primarily utilizes two conventional kinesins, an Unc104/KIF1 kinesin, and cytoplasmic dynein to transport membrane organelles within its cytoplasm. We describe how the biological functions of these motors has been dissected through a combination of biochemical to genetic approaches.

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收藏

页码：631 / 638

页数：8

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