Comparison of in vitro activities of voriconazole and five established antifungal agents against different species of dermatophytes using a broth macrodilution method

被引:74
作者
Perea, S
Fothergill, AW
Sutton, DA
Rinaldi, MG
机构
[1] Univ Texas, Hlth Sci Ctr, Dept Pathol, San Antonio, TX 78284 USA
[2] S Texas Vet Hlth Care Syst, Audie Murphy Div, San Antonio, TX 78284 USA
关键词
D O I
10.1128/JCM.39.1.385-388.2001
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The in vitro activities of voriconazole against 19 different species of dermatophytes were compared with those of terbinafine, itraconazole, ketoconazole, griseofulvin, and fluconazole. MICs were determined according to a National Committee for Clinical Laboratory Standards broth macrodilution method. Voriconazole appeared more active than ketoconazole, griseofulvin, and fluconazole and less active than itraconazole and terbinafine. Based on these results, voriconazole merits further investigation as a potentially useful agent for the treatment of dermatophytosis.
引用
收藏
页码:385 / 388
页数:4
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