Effect of vascular endothelial growth factor on laryngeal wound healing in rabbits

OBJECTIVE: Study the effects of vascular endothelial growth factor (VEGF) on laryngeal wound healing in a rabbit model. STUDY DESIGN: Prospective, randomized, blinded. METHODS: The anterior cricoid cartilage of 10 rabbits was split and a VEGF-soaked collagen sponge was sewn between the cut edges. In 10 control animals. the collagen sponge was soaked with phosphate-buffered saline solution. The larynx was harvested on day 10. The degree of epithelial closure, the degree of soft tissue closure, and the presence of inflammatory cells was graded. RESULTS: There was complete epithelial closure in the control group. There was a slightly higher, but not statistically significant, grade of soft tissue closure in the experimental group. The experimental group had a lower but not statistically significant acute inflammatory response score. CONCLUSIONS: The topical application of VEGF through an implanted collagen sponge to an anterior, subglottic incision in a rabbit has no significant effect on tracheal luminal epithelial closure, acute inflammatory response, or soft tissue repair at postsurgical day 10. (c) 2007 American Academy of Otolaryngology-Head and Neck Surgery Foundation. All rights reserved.