A role for Th1 and Th2 cells in the immunopathogenesis of atopic dermatitis

被引：592

作者：

Grewe, M

Bruijnzeel-Koomen, CAFM

Schöpf, E

Thepen, T

Langeveld-Wildschut, AG

Ruzicka, T

Krutmann, J

机构：

[1] Univ Dusseldorf, Dept Dermatol, Clin & Expt Photodermatol, D-4000 Dusseldorf, Germany

[2] Univ Utrecht Hosp, Dept Dermatol Allergol, Utrecht, Netherlands

[3] Univ Freiburg, Dept Dermatol, D-7800 Freiburg, Germany

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 08期

关键词：

D O I：

10.1016/S0167-5699(98)01285-7

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Atopic dermatitis (AD) is a chronic inflammatory skin disease characterized by intensely pruritic subacute and chronic eczematous plaques, the pathogenesis of which appears to involve a complex interplay of genetic, pharmacological, environmental and psychological factors. Here, Markus Grewe and colleagues propose that the development of skin lesions in AD patients results from sequential activation of T helper 2 (Th2)- and Th1-type cells.

引用

页码：359 / 361

页数：3