Determination of tromethamine in an eye-care pharmaceutical by capillary electrophoresis

被引：9

作者：

McArdle, FA ^{[1
]}

Meehan, CJ ^{[1
]}

机构：

[1] Inst Technol, Dept Appl Sci, Sligo, Ireland

来源：

ANALYST | 1998年 / 123卷 / 08期

关键词：

capillary electrophoresis; eye-care pharmaceutical; indirect UV detection; tromethamine;

D O I：

10.1039/a802417k

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Tromethamine [tris(hydroxymethyl)aminomethane] is used as an emulsifying agent, alkaliser and buffering agent in pharmaceutical preparations such as eye-care solutions. A new method for the determination of this compound in an eye-care preparation was developed using capillary zone electrophoresis with indirect UV detection. The method displayed linearity between 2.5 and 25 mg I-1 with a correlation coefficient of 0.9992. The limit of detection was 2.5 mg l(-1). Precision and accuracy were determined as relative standard deviation and % deviation, and were found to be 0.42% and 1.62%, respectively. Recovery studies of tromethamine in the pharmaceutical preparation gave a 102.98% recovery.

引用

页码：1757 / 1760

页数：4

共 21 条

[1] Analysis of modified oligonucleotides by capillary electrophoresis in a polyvinylpyrrolidone matrix coupled with electrospray mass spectrometry [J].