APPLICATIONS OF CAPILLARY ELECTROPHORESIS IN THE EYE-CARE PHARMACEUTICAL-INDUSTRY

被引：18

作者：

CHADWICK, RR

HSIEH, JC

RESHAM, KS

NELSON, RB

机构：

[1] Allergan Optical, Irvine, CA 92715-2002

来源：

JOURNAL OF CHROMATOGRAPHY A | 1994年 / 671卷 / 1-2期

关键词：

D O I：

10.1016/0021-9673(94)80267-X

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The speed and resolution of capillary electrophoresis (CE), combined with its low cost and low volume requirements, make it a promising method of separating eye-care pharmaceuticals and analyzing the ionic composition of tears. Capillary zone electrophoresis (CZE) offers linearity, precision, and recovery comparable to high-performance liquid chromatography (HPLC) at a fraction of its cost. In addition, CZE separates and quantitates cocoamphocarboxyglycinate in the presence of a non-ionic fatty acid amide surfactant seven times faster than HPLC. CE easily detects such cations as sodium and potassium in human tears.

引用

页码：403 / 410

页数：8

共 16 条

[1] DETERMINATION OF CIMETIDINE IN PHARMACEUTICAL PREPARATIONS BY CAPILLARY ZONE ELECTROPHORESIS [J].