Adiponectin: Saving the starved and the overfed

被引：26

作者：

Behre, C. J. ^{[1
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Univ Hosp, Inst Internal Med, Wallenberg Lab Cardiovasc Res, Gothenburg, Sweden

来源：

MEDICAL HYPOTHESES | 2007年 / 69卷 / 06期

关键词：

D O I：

10.1016/j.mehy.2007.02.044

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The incidence of the metabolic syndrome, type 2 diabetes and cardio- and cerebrovascular disease is increasing in the Western world. The adipocyte derived protein adiponectin is thought to have a protective rote against these conditions. But why is it so? Is it reasonable to believe that we have adiponectin to gain protection from welfare related diseases? Humans have had a far deadlier foe throughout history than obesity and sedentariness and that is starvation. During starvation, the body is catabolic in order to provide fuel. Catabolism is also seen in patients with advanced cardiac or renal failure, type 1 diabetes and anorexia. These subjects have higher adiponectin levels than controls. In this article, I will put forward the hypothesis that the adiponectin system evolved in order to help us to survive periods of malnourishment. (C) 2007 Elsevier Ltd. All rights reserved.

引用

收藏

页码：1290 / 1292

页数：3

相关论文

共 30 条

[1] Plasma adiponectin concentrations do not increase in association with moderate weight loss in insulin-resistant, obese women [J].

Abbasi, F ;

Lamendola, C ;

McLaughlin, T ;

Hayden, J ;

Reaven, GM ;

Reaven, PD .

METABOLISM-CLINICAL AND EXPERIMENTAL, 2004, 53 (03) :280-283

[2]

[Anonymous], WORLD HLTH REP 2002

[3] Paradoxical decrease of an adipose-specific protein, adiponectin, in obesity [J].

Arita, Y ;

Kihara, S ;

Ouchi, N ;

Takahashi, M ;

Maeda, K ;

Miyagawa, J ;

Hotta, K ;

Shimomura, I ;

Nakamura, T ;

Miyaoka, K ;

Kuriyama, H ;

Nishida, M ;

Yamashita, S ;

Okubo, K ;

Matsubara, K ;

Muraguchi, M ;

Ohmoto, Y ;

Funahashi, T ;

Matsuzawa, Y .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1999, 257 (01) :79-83

[4] Adiponectin relationship with lipid metabolism is independent of body fat mass:: Evidence from both cross-sectional and intervention studies [J].

Baratta, R ;

Amato, S ;

Degano, C ;

Farina, MG ;

Patanè, G ;

Vigneri, R ;

Frittitta, L .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2004, 89 (06) :2665-2671

[5] Changes of adiponectin oligomer composition by moderate weight reduction [J].

Bobbert, T ;

Rochlitz, H ;

Wegewitz, U ;

Akpulat, S ;

Mai, K ;

Weickert, MO ;

Möhlig, M ;

Pfeiffer, AFH ;

Spranger, J .

DIABETES, 2005, 54 (09) :2712-2719

[6] Restoration of adiponectin pulsatility in severely obese subjects after weight loss [J].

Calvani, M ;

Scarfone, A ;

Granato, L ;

Mora, EV ;

Nanni, G ;

Castagneto, M ;

Greco, AV ;

Manco, M ;

Mingrone, G .

DIABETES, 2004, 53 (04) :939-947

[7] Hypoadiponectinemia is associated with ischemic cerebrovascular disease [J].

Chen, MP ;

Tsai, JCR ;

Chung, FM ;

Yang, SS ;

Hsing, LL ;

Shin, SJ ;

Lee, YJ .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2005, 25 (04) :821-826

[8] Hyperadiponectinaemia in anorexia nervosa [J].

Delporte, ML ;

Brichard, SM ;

Hermans, MP ;

Beguin, C ;

Lambert, M .

CLINICAL ENDOCRINOLOGY, 2003, 58 (01) :22-29

[9] Plasma adiponectin concentration in relation to severity of coronary atherosclerosis and cardiovascular risk factors in middle-aged men [J].

Dunajska, K ;

Milewicz, A ;

Jedrzejuk, D ;

Szymczak, J ;

Kuliczkowski, W ;

Salomon, P ;

Bialy, D ;

Poczatek, K ;

Nowicki, P .

ENDOCRINE, 2004, 25 (03) :215-221

[10] Adiponectin and the development of type 2 diabetes - The atherosclerosis risk in communities study [J].

Duncan, BB ;

Schmidt, MI ;

Pankow, JS ;

Bang, HJ ;

Couper, D ;

Ballantyne, CM ;

Hoogeveen, RC ;

Heiss, G .

DIABETES, 2004, 53 (09) :2473-2478