HIV infection: how effective is drug combination treatment?

被引：50

作者：

Grossman, Z ^{[1
]}

Feinberg, M

Kuznetsov, V

Dimitrov, D

Paul, W

机构：

[1] NIH, OFF AIDS Res, Bethesda, MD 20892 USA

[2] NIH, Lab Expt & Computat Biol, Frederick, MD 21702 USA

[3] Tel Aviv Univ, Sackler Fac Med, Dept Physiol & Pharmacol, IL-69978 Tel Aviv, Israel

来源：

IMMUNOLOGY TODAY | 1998年 / 19卷 / 11期

关键词：

D O I：

10.1016/S0167-5699(98)01353-X

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The rate of decline of plasma HIV RNA in patients treated with anti-retroviral drugs has been postulated to reflect the half-lives of previously HIV-infected cells. Here, Zvi Grossman and colleagues argue that the observed decline is explained by the kinetics of ongoing infection cycles. Residual cell-to-cell infection that becomes increasingly difficult to block could stabilize cellular provirus reservoirs.

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收藏

页码：528 / 532

页数：5

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