Asymmetric chemo- and regiospecific addition of organozinc reagents to Baylis-Hillman derived allylic electrophiles

被引：48

作者：

Börner, C

Gimeno, J

Gladiali, S

Goldsmith, PJ

Ramazzotti, D

Woodward, S

机构：

[1] Univ Nottingham, Sch Chem, Nottingham NG7 2RD, England

[2] Univ Autonoma Barcelona, Dept Quim, E-08193 Barcelona, Spain

[3] Univ Sassari, Dipartimento Chim, I-07100 Sassari, Italy

来源：

CHEMICAL COMMUNICATIONS | 2000年 / 24期

关键词：

D O I：

10.1039/b006943o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The copper-catalysed S(N)2' addition of ZnR2 to allylic (Z)-ArCH=C(CH2X)(CO2Et) (X = Br, Cl, OSO2Me) fashions only ArCH(R)C(=CH2)(CO2Et); use of a chiral ligand gives up to 64% ee for this demanding reaction.

引用

页码：2433 / 2434

页数：2

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