MT5-MMP, just a new APP processing proteinase in Alzheimer's disease?

被引：19

作者：

Baranger, Kevin ^{[1
]}

Khrestchatisky, Michel ^{[1
]}

Rivera, Santiago ^{[1
]}

机构：

[1] Aix Marseille Univ, CNRS, NICN, Marseille, France

来源：

JOURNAL OF NEUROINFLAMMATION | 2016年 / 13卷

关键词：

Matrix metalloproteinases; Neurodegenerative disease; Trafficking; Neuroinflammation; IL-1; beta; Amyloidogenesis; Amyloid precursor protein; MATRIX-METALLOPROTEINASE MT5-MMP; NERVOUS-SYSTEM; MEMBRANE; IDENTIFICATION; CLEAVAGE; BRAIN; INHIBITORS; BINDING; INJURY;

D O I：

10.1186/s12974-016-0633-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

071005 [微生物学]; 100108 [医学免疫学];

摘要：

We have recently identified in a transgenic mouse model of Alzheimer's disease (AD) membrane-type 5-MMP (MT5-MMP) as a new player in Alzheimer's pathogenesis, which displays pro-amyloidogenic features and proteolytic processing of amyloid precursor protein (APP). Another group has reported that MT5-MMP processing of APP may release a novel neurotoxic APP fragment. Although MT5-MMP-mediated APP processing appears to be a key pathogenic step, we hypothesize that MT5-MMP may also contribute to AD pathogenesis through complementary mechanisms that involve the activation of pro-inflammatory pathways and/or APP trafficking.

引用

页数：4

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