Evaluation of cytogenetic effects of lambda-cyhalothrin on Wistar rat bone marrow by gavage administration

In this study, a synthetic pyrethroid insecticide, lambda-cyhalothrin (LCT), was administered to adult female albino rats (Wistar rats) by gavage dose of 6.12, 3.06, 0.8 mg/kg b.w. repeated for 13 days at 48 h intervals. The cytotoxic and genotoxic effects of LCT were investigated in bone marrow cells, using the structural chromosomal aberration (SCA) and micronucleus (MN) test systems. Mitomycin C (MMC) was also used as positive control (2 mg/kg b.w.). All the doses of LCT increased the number of SCAs and the frequency of micronucleated erythrocytes, with respect to the control group. Only the highest dose of LCT significantly increased the MN frequency compared with control (P < 0.01). It was also observed that LCT caused a significant decrease in the number of polychromatic erythrocytes compared with controls (p < 0.001). These observations indicate the in vivo suspectibility of mammals to the genetic toxicity and cytotoxicity potential of LCT. (c) 2004 Elsevier Inc. All rights reserved.