共 47 条
MF59 Adjuvant Enhances Diversity and Affinity of Antibody-Mediated Immune Response to Pandemic Influenza Vaccines
被引:288
作者:

Khurana, Surender
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h-index: 0
机构:
US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA

Verma, Nitin
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h-index: 0
机构:
US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA

Yewdell, Jonathan W.
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA

Hilbert, Anne Katrin
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h-index: 0
机构:
Novartis Vaccines & Diagnost GmbH, D-35041 Marburg, Germany US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA

Castellino, Flora
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h-index: 0
机构:
Novartis Vaccines & Diagnost Res Ctr, I-53100 Siena, Italy US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA

Lattanzi, Maria
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Vaccines & Diagnost Res Ctr, I-53100 Siena, Italy US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA

Del Giudice, Giuseppe
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Vaccines & Diagnost Res Ctr, I-53100 Siena, Italy US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA

Rappuoli, Rino
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h-index: 0
机构:
Novartis Vaccines & Diagnost Res Ctr, I-53100 Siena, Italy US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA

Golding, Hana
论文数: 0 引用数: 0
h-index: 0
机构:
US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA
机构:
[1] US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Bethesda, MD 20892 USA
[2] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA
[3] Novartis Vaccines & Diagnost GmbH, D-35041 Marburg, Germany
[4] Novartis Vaccines & Diagnost Res Ctr, I-53100 Siena, Italy
关键词:
A H1N1 VACCINE;
CELL RESPONSE;
H5N1;
VACCINE;
VIRUS;
IMMUNOGENICITY;
MATURATION;
SAFETY;
NEUTRALIZATION;
ANTIGEN;
RECOGNITION;
D O I:
10.1126/scitranslmed.3002336
中图分类号:
Q2 [细胞生物学];
学科分类号:
071009 ;
090102 ;
摘要:
Oil-in-water adjuvants have been shown to improve immune responses against pandemic influenza vaccines as well as reduce the effective vaccine dose, increasing the number of doses available to meet global vaccine demand. Here, we use genome fragment phage display libraries and surface plasmon resonance to elucidate the effects of MF59 on the quantity, diversity, specificity, and affinity maturation of human antibody responses to the swine-origin H1N1 vaccine in different age groups. In adults and children, MF59 selectively enhanced antibody responses to the hemagglutinin 1 (HA1) globular head relative to the more conserved HA2 domain in terms of increased antibody titers as well as a more diverse antibody epitope repertoire. Antibody affinity, as inferred by greatly diminished (>= 10-fold) off-rate constants, was significantly increased in toddlers and children who received the MF59-adjuvanted vaccine. Moreover, MF59 also improved antibody affinity maturation after each sequential vaccination against avian H5N1 in adults. For both pandemic influenza vaccines, there was a close correlation between serum antibody affinity and virus-neutralizing capacity. Thus, MF59 quantitatively and qualitatively enhances functional antibody responses to HA-based vaccines by improving both epitope breadth and binding affinity, demonstrating the added value of such adjuvants for influenza vaccines.
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相关论文
共 47 条
[1]
Pseudoparticle neutralization is a reliable assay to measure immunity and cross-reactivity to H5N1 influenza viruses
[J].
Alberini, Isabella
;
Del Tordello, Elena
;
Fasolo, Alba
;
Temperton, Nigel J.
;
Galli, Grazia
;
Gentile, Chiara
;
Montomoli, Emanuele
;
Hilbert, Anne K.
;
Banzhoff, Angelika
;
Del Giudice, Giuseppe
;
Donnelly, John J.
;
Rappuoli, Rino
;
Capecchi, Barbara
.
VACCINE,
2009, 27 (43)
:5998-6003

Alberini, Isabella
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Vaccines, Siena, Italy Novartis Vaccines, Siena, Italy

Del Tordello, Elena
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Vaccines, Siena, Italy Novartis Vaccines, Siena, Italy

Fasolo, Alba
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Vaccines, Siena, Italy Novartis Vaccines, Siena, Italy

Temperton, Nigel J.
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Ctr Med Mol Virol, Div Infect & Immun, London WC1E 6BT, England Novartis Vaccines, Siena, Italy

Galli, Grazia
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Vaccines, Siena, Italy Novartis Vaccines, Siena, Italy

Gentile, Chiara
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Siena, Dept Physiopathol Expt Med & Publ Hlth, Lab Mol Epidemiol, I-53100 Siena, Italy Novartis Vaccines, Siena, Italy

Montomoli, Emanuele
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Siena, Dept Physiopathol Expt Med & Publ Hlth, Lab Mol Epidemiol, I-53100 Siena, Italy Novartis Vaccines, Siena, Italy

Hilbert, Anne K.
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Vaccines, Marburg, Germany Novartis Vaccines, Siena, Italy

Banzhoff, Angelika
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Vaccines, Marburg, Germany Novartis Vaccines, Siena, Italy

Del Giudice, Giuseppe
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Vaccines, Siena, Italy Novartis Vaccines, Siena, Italy

Donnelly, John J.
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Vaccines, Siena, Italy Novartis Vaccines, Siena, Italy

Rappuoli, Rino
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Vaccines, Siena, Italy Novartis Vaccines, Siena, Italy

Capecchi, Barbara
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Vaccines, Siena, Italy Novartis Vaccines, Siena, Italy
[2]
Neutralizing antiviral B cell responses
[J].
Bachmann, MF
;
Zinkernagel, RM
.
ANNUAL REVIEW OF IMMUNOLOGY,
1997, 15
:235-270

Bachmann, MF
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV ZURICH, DEPT PATHOL, INST EXPT IMMUNOL, CH-8091 ZURICH, SWITZERLAND UNIV ZURICH, DEPT PATHOL, INST EXPT IMMUNOL, CH-8091 ZURICH, SWITZERLAND

Zinkernagel, RM
论文数: 0 引用数: 0
h-index: 0
机构:
UNIV ZURICH, DEPT PATHOL, INST EXPT IMMUNOL, CH-8091 ZURICH, SWITZERLAND UNIV ZURICH, DEPT PATHOL, INST EXPT IMMUNOL, CH-8091 ZURICH, SWITZERLAND
[3]
The role of antibody concentration and avidity in antiviral protection
[J].
Bachmann, MF
;
Kalinke, U
;
Althage, A
;
Freer, G
;
Burkhart, C
;
Roost, HP
;
Aguet, M
;
Hengartner, H
;
Zinkernagel, RM
.
SCIENCE,
1997, 276 (5321)
:2024-2027

Bachmann, MF
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ZURICH HOSP,INST EXPT IMMUNOL,DEPT PATHOL,CH-8091 ZURICH,SWITZERLAND

Kalinke, U
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ZURICH HOSP,INST EXPT IMMUNOL,DEPT PATHOL,CH-8091 ZURICH,SWITZERLAND

Althage, A
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ZURICH HOSP,INST EXPT IMMUNOL,DEPT PATHOL,CH-8091 ZURICH,SWITZERLAND

Freer, G
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ZURICH HOSP,INST EXPT IMMUNOL,DEPT PATHOL,CH-8091 ZURICH,SWITZERLAND

Burkhart, C
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ZURICH HOSP,INST EXPT IMMUNOL,DEPT PATHOL,CH-8091 ZURICH,SWITZERLAND

Roost, HP
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ZURICH HOSP,INST EXPT IMMUNOL,DEPT PATHOL,CH-8091 ZURICH,SWITZERLAND

Aguet, M
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ZURICH HOSP,INST EXPT IMMUNOL,DEPT PATHOL,CH-8091 ZURICH,SWITZERLAND

Hengartner, H
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ZURICH HOSP,INST EXPT IMMUNOL,DEPT PATHOL,CH-8091 ZURICH,SWITZERLAND

Zinkernagel, RM
论文数: 0 引用数: 0
h-index: 0
机构: UNIV ZURICH HOSP,INST EXPT IMMUNOL,DEPT PATHOL,CH-8091 ZURICH,SWITZERLAND
[4]
Affinity dependence of the B cell response to antigen: A threshold, a ceiling, and the importance of off-rate
[J].
Batista, FD
;
Neuberger, MS
.
IMMUNITY,
1998, 8 (06)
:751-759

Batista, FD
论文数: 0 引用数: 0
h-index: 0
机构:
MRC, Mol Biol Lab, Cambridge CB2 2QH, England MRC, Mol Biol Lab, Cambridge CB2 2QH, England

Neuberger, MS
论文数: 0 引用数: 0
h-index: 0
机构:
MRC, Mol Biol Lab, Cambridge CB2 2QH, England MRC, Mol Biol Lab, Cambridge CB2 2QH, England
[5]
Safety and Immunogenicity of Multiple and Higher Doses of an Inactivated Influenza A/H5N1 Vaccine
[J].
Beigel, John H.
;
Voell, Jocelyn
;
Huang, Chiung-yu
;
Burbelo, Peter D.
;
Lane, H. Clifford
.
JOURNAL OF INFECTIOUS DISEASES,
2009, 200 (04)
:501-509

Beigel, John H.
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, NIH, Bethesda, MD 20892 USA NIAID, NIH, Bethesda, MD 20892 USA

Voell, Jocelyn
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, NIH, Bethesda, MD 20892 USA NIAID, NIH, Bethesda, MD 20892 USA

Huang, Chiung-yu
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, NIH, Bethesda, MD 20892 USA NIAID, NIH, Bethesda, MD 20892 USA

Burbelo, Peter D.
论文数: 0 引用数: 0
h-index: 0
机构:
Natl Inst Dent & Craniofacial Res, NIH, Bethesda, MD 20892 USA NIAID, NIH, Bethesda, MD 20892 USA

Lane, H. Clifford
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, NIH, Bethesda, MD 20892 USA NIAID, NIH, Bethesda, MD 20892 USA
[6]
Effects of adjuvants on the safety and immunogenicity of an avian influenza H5N1 vaccine in adults
[J].
Bernstein, David I.
;
Edwards, Kathryn M.
;
Dekker, Cornelia L.
;
Belshe, Robert
;
Talbot, Helen K. B.
;
Graham, Irene L.
;
Noah, Diana L.
;
He, Fenhua
;
Hill, Heather
.
JOURNAL OF INFECTIOUS DISEASES,
2008, 197 (05)
:667-675

Bernstein, David I.
论文数: 0 引用数: 0
h-index: 0
机构:
Cincinnati Childrens Hosp, Med Ctr, Div Infect Dis, Cincinnati, OH USA Cincinnati Childrens Hosp, Med Ctr, Div Infect Dis, Cincinnati, OH USA

Edwards, Kathryn M.
论文数: 0 引用数: 0
h-index: 0
机构: Cincinnati Childrens Hosp, Med Ctr, Div Infect Dis, Cincinnati, OH USA

Dekker, Cornelia L.
论文数: 0 引用数: 0
h-index: 0
机构:
Stanford Univ, Sch Med, Stanford, CA USA Cincinnati Childrens Hosp, Med Ctr, Div Infect Dis, Cincinnati, OH USA

Belshe, Robert
论文数: 0 引用数: 0
h-index: 0
机构:
St Louis Univ, St Louis, MO 63103 USA Cincinnati Childrens Hosp, Med Ctr, Div Infect Dis, Cincinnati, OH USA

Talbot, Helen K. B.
论文数: 0 引用数: 0
h-index: 0
机构: Cincinnati Childrens Hosp, Med Ctr, Div Infect Dis, Cincinnati, OH USA

Graham, Irene L.
论文数: 0 引用数: 0
h-index: 0
机构:
St Louis Univ, St Louis, MO 63103 USA Cincinnati Childrens Hosp, Med Ctr, Div Infect Dis, Cincinnati, OH USA

Noah, Diana L.
论文数: 0 引用数: 0
h-index: 0
机构:
So Res Inst, Birmingham, AL 35255 USA Cincinnati Childrens Hosp, Med Ctr, Div Infect Dis, Cincinnati, OH USA

He, Fenhua
论文数: 0 引用数: 0
h-index: 0
机构:
EMMES, Rockville, MD USA Cincinnati Childrens Hosp, Med Ctr, Div Infect Dis, Cincinnati, OH USA

Hill, Heather
论文数: 0 引用数: 0
h-index: 0
机构:
EMMES, Rockville, MD USA Cincinnati Childrens Hosp, Med Ctr, Div Infect Dis, Cincinnati, OH USA
[7]
Immunogenicity and safety of AS03-adjuvanted 2009 influenza A H1N1 vaccine in children 6-35 months
[J].
Carmona, Alfonso
;
Omenaca, Felix
;
Tejedor, Juan C.
;
Merino, Jose M.
;
Vaman, Tejaswini
;
Dieussaert, Ilse
;
Gillard, Paul
;
Aristegui, Javier
.
VACCINE,
2010, 28 (36)
:5837-5844

Carmona, Alfonso
论文数: 0 引用数: 0
h-index: 0
机构:
Inst Hispalense & Pediat, Seville, Spain Inst Hispalense & Pediat, Seville, Spain

Omenaca, Felix
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp La Paz, Madrid, Spain Inst Hispalense & Pediat, Seville, Spain

Tejedor, Juan C.
论文数: 0 引用数: 0
h-index: 0
机构:
Mostoles Hosp, Madrid, Spain Inst Hispalense & Pediat, Seville, Spain

Merino, Jose M.
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Gen Yague, Burgos, Spain Inst Hispalense & Pediat, Seville, Spain

Vaman, Tejaswini
论文数: 0 引用数: 0
h-index: 0
机构:
GlaxoSmithKline Biol, Wavre, Belgium Inst Hispalense & Pediat, Seville, Spain

Dieussaert, Ilse
论文数: 0 引用数: 0
h-index: 0
机构:
GlaxoSmithKline Biol, Wavre, Belgium Inst Hispalense & Pediat, Seville, Spain

Gillard, Paul
论文数: 0 引用数: 0
h-index: 0
机构:
GlaxoSmithKline Biol, Wavre, Belgium Inst Hispalense & Pediat, Seville, Spain

Aristegui, Javier
论文数: 0 引用数: 0
h-index: 0
机构:
Basurto Hosp, Bilbao, Spain Inst Hispalense & Pediat, Seville, Spain
[8]
Severe pandemic 2009 H1N1 influenza disease due to pathogenic immune complexes
[J].
Clara Monsalvo, Ana
;
Batalle, Juan P.
;
Florencia Lopez, M.
;
Krause, Jens C.
;
Klemenc, Jennifer
;
Zea Hernandez, Johanna
;
Maskin, Bernardo
;
Bugna, Jimena
;
Rubinstein, Carlos
;
Aguilar, Leandro
;
Dalurzo, Liliana
;
Libster, Romina
;
Savy, Vilma
;
Baumeister, Elsa
;
Aguilar, Liliana
;
Cabral, Graciela
;
Font, Julia
;
Solari, Liliana
;
Weller, Kevin P.
;
Johnson, Joyce
;
Echavarria, Marcela
;
Edwards, Kathryn M.
;
Chappell, James D.
;
Crowe, James E., Jr.
;
Williams, John V.
;
Melendi, Guillermina A.
;
Polack, Fernando P.
.
NATURE MEDICINE,
2011, 17 (02)
:195-U225

Clara Monsalvo, Ana
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn INFANT, Buenos Aires, DF, Argentina Fdn INFANT, Buenos Aires, DF, Argentina

Batalle, Juan P.
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn INFANT, Buenos Aires, DF, Argentina Fdn INFANT, Buenos Aires, DF, Argentina

Florencia Lopez, M.
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn INFANT, Buenos Aires, DF, Argentina Fdn INFANT, Buenos Aires, DF, Argentina

Krause, Jens C.
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Dept Pediat, Nashville, TN USA Fdn INFANT, Buenos Aires, DF, Argentina

Klemenc, Jennifer
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Dept Pediat, Nashville, TN USA Fdn INFANT, Buenos Aires, DF, Argentina

Zea Hernandez, Johanna
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn INFANT, Buenos Aires, DF, Argentina
Vanderbilt Univ, Dept Pediat, Nashville, TN USA Fdn INFANT, Buenos Aires, DF, Argentina

Maskin, Bernardo
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Nacl Prof Alejandro Posadas, Buenos Aires, DF, Argentina Fdn INFANT, Buenos Aires, DF, Argentina

Bugna, Jimena
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn INFANT, Buenos Aires, DF, Argentina Fdn INFANT, Buenos Aires, DF, Argentina

Rubinstein, Carlos
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Dr Federico Abete, Buenos Aires, DF, Argentina Fdn INFANT, Buenos Aires, DF, Argentina

Aguilar, Leandro
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Dr Federico Abete, Buenos Aires, DF, Argentina Fdn INFANT, Buenos Aires, DF, Argentina

Dalurzo, Liliana
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Italiano Buenos Aires, Buenos Aires, DF, Argentina Fdn INFANT, Buenos Aires, DF, Argentina

Libster, Romina
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn INFANT, Buenos Aires, DF, Argentina Fdn INFANT, Buenos Aires, DF, Argentina

Savy, Vilma
论文数: 0 引用数: 0
h-index: 0
机构:
Adm Nacl Labs, Buenos Aires, DF, Argentina
Inst Salud Dr Carlos G Malbran, Buenos Aires, DF, Argentina Fdn INFANT, Buenos Aires, DF, Argentina

Baumeister, Elsa
论文数: 0 引用数: 0
h-index: 0
机构:
Adm Nacl Labs, Buenos Aires, DF, Argentina
Inst Salud Dr Carlos G Malbran, Buenos Aires, DF, Argentina Fdn INFANT, Buenos Aires, DF, Argentina

Aguilar, Liliana
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Nacl Prof Alejandro Posadas, Buenos Aires, DF, Argentina Fdn INFANT, Buenos Aires, DF, Argentina

Cabral, Graciela
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Nacl Prof Alejandro Posadas, Buenos Aires, DF, Argentina Fdn INFANT, Buenos Aires, DF, Argentina

Font, Julia
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Nacl Prof Alejandro Posadas, Buenos Aires, DF, Argentina Fdn INFANT, Buenos Aires, DF, Argentina

Solari, Liliana
论文数: 0 引用数: 0
h-index: 0
机构:
Hosp Nacl Prof Alejandro Posadas, Buenos Aires, DF, Argentina Fdn INFANT, Buenos Aires, DF, Argentina

Weller, Kevin P.
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Dept Pediat, Nashville, TN USA Fdn INFANT, Buenos Aires, DF, Argentina

Johnson, Joyce
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Dept Pathol, Nashville, TN USA Fdn INFANT, Buenos Aires, DF, Argentina

Echavarria, Marcela
论文数: 0 引用数: 0
h-index: 0
机构:
Ctr Educ Med & Invest Clin, Dept Microbiol, Buenos Aires, DF, Argentina Fdn INFANT, Buenos Aires, DF, Argentina

Edwards, Kathryn M.
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Dept Pediat, Nashville, TN USA Fdn INFANT, Buenos Aires, DF, Argentina

Chappell, James D.
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Dept Pathol, Nashville, TN USA Fdn INFANT, Buenos Aires, DF, Argentina

Crowe, James E., Jr.
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Dept Pediat, Nashville, TN USA Fdn INFANT, Buenos Aires, DF, Argentina

Williams, John V.
论文数: 0 引用数: 0
h-index: 0
机构:
Vanderbilt Univ, Dept Pediat, Nashville, TN USA Fdn INFANT, Buenos Aires, DF, Argentina

Melendi, Guillermina A.
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn INFANT, Buenos Aires, DF, Argentina
Vanderbilt Univ, Dept Pediat, Nashville, TN USA Fdn INFANT, Buenos Aires, DF, Argentina

Polack, Fernando P.
论文数: 0 引用数: 0
h-index: 0
机构:
Fdn INFANT, Buenos Aires, DF, Argentina
Vanderbilt Univ, Dept Pediat, Nashville, TN USA Fdn INFANT, Buenos Aires, DF, Argentina
[9]
Trial of 2009 Influenza A (H1N1) Monovalent MF59-Adjuvanted Vaccine.
[J].
Clark, Tristan W.
;
Pareek, Manish
;
Hoschler, Katja
;
Dillon, Helen
;
Nicholson, Karl G.
;
Groth, Nicola
;
Stephenson, Iain
.
NEW ENGLAND JOURNAL OF MEDICINE,
2009, 361 (25)
:2424-2435

Clark, Tristan W.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Leicester, Dept Inflammat Infect & Immun, Leicester, Leics, England Univ Leicester, Leicester Royal Infirm, Infect Dis Unit, Univ Hosp Leicester, Leicester, Leics, England

Pareek, Manish
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Leicester, Dept Inflammat Infect & Immun, Leicester, Leics, England Univ Leicester, Leicester Royal Infirm, Infect Dis Unit, Univ Hosp Leicester, Leicester, Leics, England

Hoschler, Katja
论文数: 0 引用数: 0
h-index: 0
机构:
Hlth Protect Agcy, Resp Virus Lab, London, England Univ Leicester, Leicester Royal Infirm, Infect Dis Unit, Univ Hosp Leicester, Leicester, Leics, England

Dillon, Helen
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Leicester, Dept Inflammat Infect & Immun, Leicester, Leics, England Univ Leicester, Leicester Royal Infirm, Infect Dis Unit, Univ Hosp Leicester, Leicester, Leics, England

Nicholson, Karl G.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Leicester, Dept Inflammat Infect & Immun, Leicester, Leics, England Univ Leicester, Leicester Royal Infirm, Infect Dis Unit, Univ Hosp Leicester, Leicester, Leics, England

Groth, Nicola
论文数: 0 引用数: 0
h-index: 0
机构:
Novartis Vaccines & Diagnost, Siena, Italy Univ Leicester, Leicester Royal Infirm, Infect Dis Unit, Univ Hosp Leicester, Leicester, Leics, England

Stephenson, Iain
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Leicester, Leicester Royal Infirm, Infect Dis Unit, Univ Hosp Leicester, Leicester, Leics, England
Univ Leicester, Dept Inflammat Infect & Immun, Leicester, Leics, England Univ Leicester, Leicester Royal Infirm, Infect Dis Unit, Univ Hosp Leicester, Leicester, Leics, England
[10]
Vaccine Adjuvants: Putting Innate Immunity to Work
[J].
Coffman, Robert L.
;
Sher, Alan
;
Seder, Robert A.
.
IMMUNITY,
2010, 33 (04)
:492-503

Coffman, Robert L.
论文数: 0 引用数: 0
h-index: 0
机构:
Dynavax Technol Corp, Berkeley, CA 94710 USA Dynavax Technol Corp, Berkeley, CA 94710 USA

Sher, Alan
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h-index: 0
机构:
NIAID, Parasit Dis Lab, Bethesda, MD 20892 USA Dynavax Technol Corp, Berkeley, CA 94710 USA

Seder, Robert A.
论文数: 0 引用数: 0
h-index: 0
机构:
NIAID, Cellular Immunol Sect, Vaccine Res Ctr, Bethesda, MD 20892 USA Dynavax Technol Corp, Berkeley, CA 94710 USA