HLA-G: from biology to clinical benefits

被引：315

作者：

Carosella, Edgardo D. ^{[1
]}

Moreau, Philippe ^{[1
]}

LeMaoult, Joeel ^{[1
]}

Rouas-Freiss, Nathalie ^{[1
]}

机构：

[1] Inst Univ Hematol, Serv Rech Hematoiimunol, Hop St Louis, CEA DSV I2BM, F-75010 Paris, France

来源：

TRENDS IN IMMUNOLOGY | 2008年 / 29卷 / 03期

关键词：

D O I：

10.1016/j.it.2007.11.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The relevance of the nonclassical human leukocyte antigen (HILA) class I molecule HLA-G in human physiological and pathological contexts has been the center of intense investigation. In light of the recent advances, we report here the clinical implications of HLA-G as a tolerogenic molecule promoting uterine implantation of the embryo or acceptance of solid allografts while allowing the evasion of tumors or viruses from the immune response. These recent findings are important in terms of clinical benefits at both diagnostic and therapeutic levels.

引用

页码：125 / 132

页数：8

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