HLA-G: from biology to clinical benefits

被引：315

作者：

Carosella, Edgardo D. ^{[1
]}

Moreau, Philippe ^{[1
]}

LeMaoult, Joeel ^{[1
]}

Rouas-Freiss, Nathalie ^{[1
]}

机构：

[1] Inst Univ Hematol, Serv Rech Hematoiimunol, Hop St Louis, CEA DSV I2BM, F-75010 Paris, France

来源：

TRENDS IN IMMUNOLOGY | 2008年 / 29卷 / 03期

关键词：

D O I：

10.1016/j.it.2007.11.005

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The relevance of the nonclassical human leukocyte antigen (HILA) class I molecule HLA-G in human physiological and pathological contexts has been the center of intense investigation. In light of the recent advances, we report here the clinical implications of HLA-G as a tolerogenic molecule promoting uterine implantation of the embryo or acceptance of solid allografts while allowing the evasion of tumors or viruses from the immune response. These recent findings are important in terms of clinical benefits at both diagnostic and therapeutic levels.

引用

页码：125 / 132

页数：8

共 77 条

[11] HLA-G in murine peripheral blood after interruption of pregnancy [J].

Dendrinos, S ;

Kalabalikis, G ;

Makrakis, E ;

Papasteriades, C ;

Creatsas, G ;

Katsorchis, T .

CELL BIOLOGY INTERNATIONAL, 2005, 29 (06) :402-407

[12] Elevated levels of soluble non-classical major histocompatibility class I molecule human leucocyte antigen (HLA)-G in the blood of HIV-infected patients with or without visceral leishmaniasis [J].

Donaghy, L. ;

Gros, F. ;

Amiot, L. ;

Mary, C. ;

Maillard, A. ;

Guiguen, C. ;

Gangneux, J. -P. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2007, 147 (02) :236-240

[13] Intrathecal synthesis of soluble HLA-G and HLA-I molecules are reciprocally associated to clinical and MRI activity in patients with multiple sclerosis [J].

Fainardi, E ;

Rizzo, R ;

Melchiorri, L ;

Castellazzi, M ;

Paolino, E ;

Tola, MR ;

Granieri, E ;

Baricordi, OR .

MULTIPLE SCLEROSIS JOURNAL, 2006, 12 (01) :2-12

[14] Research on HLA-G: an update [J].

Favier, B. ;

LeMaoult, J. ;

Rouas-Freiss, N. ;

Moreau, P. ;

Menier, C. ;

Carosella, E. D. .

TISSUE ANTIGENS, 2007, 69 (03) :207-211

[15] HLA-G expression defines a novel regulatory T-cell subset present in human peripheral blood and sites of inflammation [J].

Feger, Ute ;

Tolosa, Eva ;

Huang, Yu-Hwa ;

Waschbisch, Anne ;

Biedermann, Tilo ;

Melms, Arthur ;

Wiendl, Heinz .

BLOOD, 2007, 110 (02) :568-577

[16] Soluble HLA-G1 inhibits angiogenesis through an apoptotic pathway and by direct binding to CD160 receptor expressed by endothelial cells [J].

Fons, Pierre ;

Chabot, Sophie ;

Cartwright, Judith E. ;

Lenfant, Francoise ;

L'Faqihi, Fatima ;

Giustiniani, Jerome ;

Herault, Jean-Pascal ;

Gueguen, Genevieve ;

Bono, Frangoise ;

Savi, Pierre ;

Aguerre-Girr, Maryse ;

Fournel, Sylvie ;

Malecaze, Francois ;

Bensussan, Armand ;

Plouet, Jean ;

Le Bouteiller, Philippe .

BLOOD, 2006, 108 (08) :2608-2615

[17] HLA-G is associated with pemphigus vulgaris in Jewish patients [J].

Gazit, E ;

Slomov, Y ;

Goldberg, I ;

Brenner, S ;

Loewenthal, R .

HUMAN IMMUNOLOGY, 2004, 65 (01) :39-46

[18] HLA-G expression is induced in Epstein-Barr virus-transformed B-cell lines by culture conditions [J].

Gazit, Ephraim ;

Sherf, Maya ;

Balbin, Elkana ;

Muratov, Anna ;

Goldstein, Itamar ;

Loewenthal, Ron .

HUMAN IMMUNOLOGY, 2007, 68 (06) :463-468

[19] The 14-bp deletion polymorphism in the HLA-G gene displays significant differences between ulcerative colitis and Crohn's disease and is associated with ileocecal resection in Crohn's disease [J].

Glas, Juergen ;

Toeroek, Helga-Paula ;

Tonenchi, Laurian ;

Wetzke, Martin ;

Beynon, Vanessa ;

Teshome, Molla Y. ;

Cotofana, Sebastian ;

Schiemann, Uwe ;

Griga, Thomas ;

Klein, Wolfram ;

Epplen, Joerg T. ;

Folwaczny, Christian ;

Folwaczny, Matthias ;

Mussack, Thomas ;

Weiss, Elisabeth H. .

INTERNATIONAL IMMUNOLOGY, 2007, 19 (05) :621-626

[20] The CD85J/leukocyte inhibitory receptor-1 distinguishes between conformed and β2-microglobulin-free HLA-G molecules [J].

Gonen-Gross, T ;

Achdout, H ;

Arnon, TI ;

Gazit, R ;

Stern, N ;

Horejsí, V ;

Goldman-Wohl, D ;

Yagel, S ;

Mandelboim, O .

JOURNAL OF IMMUNOLOGY, 2005, 175 (08) :4866-4874

← 1 2 3 4 5 6 7 8 →