Prediction of ADMET properties

被引：233

作者：

Norinder, Ulf

Bergstrom, Christel A. S.

机构：

[1] AstraZeneca Research and Development Södertälje

[2] Center of Pharmaceutical Informatics, Department of Pharmacy, Uppsala University, 751 23 Uppsala

来源：

CHEMMEDCHEM | 2006年 / 1卷 / 09期

关键词：

Absorption; ADMET; In silico; Predictions; Solubility;

D O I：

10.1002/cmdc.200600155

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The review de scribes some of the approa ches and technique s used today to derive in silico models for the prediction of ADMET properties. The article also discusses some of the fundamental requirements for deriving statistically sound and predictive ADMET relationships as well as some of the pitfalls and problems encountered during these investigations. It is the intension of the authors to make the reader aware of some of the challenges involved in deriving useful in silico ADMET models for drug development.

引用

收藏

页码：920 / 937

页数：18

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