HIV-1 reverse transcriptase and integrase enzymes physically interact and inhibit each other

被引：55

作者：

Tasara, T

Maga, G

Hottiger, MO

Hübscher, U

机构：

[1] Univ Zurich Irchel, Inst Vet Biochem & Mol Biol, CH-8057 Zurich, Switzerland

[2] CNR, Ist Genet Biochim & Evoluzionist, I-27100 Pavia, Italy

来源：

FEBS LETTERS | 2001年 / 507卷 / 01期

关键词：

reverse transcription; integration; preintegration complex;

D O I：

10.1016/S0014-5793(01)02945-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ordered molecular interactions and structural changes must take place within the human immunodeficiency virus type 1 (HIV-1) preintegration complex at various stages for successful viral replication. We demonstrate both physical and biochemical interactions between HIV-1 reverse transcriptase and integrase enzymes. This interaction may have implications on the in vivo functions of the two enzyme; within the HIV-1 replication complex. It may be one of the various molecular interactions, which facilitate efficient HIV-1 replication within the target cells. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

引用

页码：39 / 44

页数：6

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