Effect of age on cytokine production in humans

被引：28

作者：

Bernstein, ED ^{[1
]}

Murasko, DM ^{[1
]}

机构：

[1] Med Coll Penn & Hahnemann Univ, Sch Med, Dept Microbiol & Immunol, Philadelphia, PA 19129 USA

来源：

AGE | 1998年 / 21卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1007/s11357-998-0024-6

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Aging is accompanied by many changes in immune response, with the most consistent and dramatic alterations occurring within the T cell compartment. Since cytokines are central to immune cell communications, age-associated changes in cytokine production may contribute to these alterations. While data from murine studies suggest a switch from a Th1 (IL-2, IFN gamma) to a Th2 (IL-4, IL-6, IL-10) cytokine response, this model has not been as clearly established in humans. In addition, this current review of over 50 stud ies in humans suggests that age-associated changes in cytokine production are not consistent.

引用

页码：137 / 151

页数：15

共 62 条

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