Aspergillus nidulans natural product biosynthesis is regulated by mpkB, a putative pheromone response mitogen-activated protein kinase

被引：46

作者：

Atoui, Ali ^{[1
]}

Bao, Dapeng ^{[1
]}

Kaur, Navgeet ^{[1
]}

Grayburn, W. Scott ^{[1
]}

Calvo, Ana M. ^{[1
]}

机构：

[1] No Illinois Univ, Dept Biol Sci, De Kalb, IL 60115 USA

来源：

APPLIED AND ENVIRONMENTAL MICROBIOLOGY | 2008年 / 74卷 / 11期

关键词：

D O I：

10.1128/AEM.02842-07

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

The Aspergillus nidulans putative mitogen-activated protein kinase encoded by mpkB has a role in natural product biosynthesis. An mpkB mutant exhibited a decrease in sterigmatocystin gene expression and low mycotoxin levels. The mutation also affected the expression of genes involved in penicillin and terrequinone A synthesis. mpkB was necessary for normal expression of laeA, which has been found to regulate secondary metabolism gene clusters.

引用

页码：3596 / 3600

页数：5

共 47 条

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