Generation of reactive oxygen species by a persultide (BnSSH)

被引：63

作者：

Chatterji, T

Keerthi, K

Gates, KS ^{[1
]}

机构：

[1] Univ Missouri, Dept Chem, Columbia, MO 65211 USA

[2] Univ Missouri, Dept Biochem, Columbia, MO 65211 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 17期

关键词：

D O I：

10.1016/j.bmcl.2005.05.110

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Hydropersulfides (RSxSH) have been implicated as important intermediates in the cell-killing action of the anticancer natural products leinamycin and varacin. It has been suggested that persulfides can mediate the conversion of molecular oxygen to reactive oxygen species (O-2(.-), H2O2, and HO.). Here, experiments with synthetic benzyl hydrodisulfide (BnSSH) provide direct evidence that persulfides readily decompose to produce reactive oxygen species under physiologically relevant conditions. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：3921 / 3924

页数：4

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