A 128x128 CMOS biosensor array for extracellular recording of neural activity

被引：288

作者：

Eversmann, B ^{[1
]}

Jenkner, M

Hofmann, F

Paulus, C

Brederlow, R

Holzapfl, B

Fromherz, P

Merz, M

Brenner, M

Schreiter, M

Gabl, R

Plehnert, K

Steinhauser, M

Eckstein, G

Schmitt-Landsiedel, D

Thewes, R

机构：

[1] Infineon Technol AG, Corp Res, D-81730 Munich, Germany

[2] Tech Univ Munich, D-80290 Munich, Germany

[3] Max Planck Inst Biochem, D-82152 Martinsried, Germany

[4] Siemens AG, D-81730 Munich, Germany

来源：

IEEE JOURNAL OF SOLID-STATE CIRCUITS | 2003年 / 38卷 / 12期

关键词：

bioelectric potentials; biological cells; biological tissues; biomedical transducers; image sensors; multi-electrode array (MEA); nervous system;

D O I：

10.1109/JSSC.2003.819174

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

Sensor arrays are a key tool in the field of neuroscience for noninvasive recording of the activity of biological networks, such as dissociated neurons or neural tissue. A high-density sensor array complementary metal-oxide-semiconductor chip is presented with 16 K pixels, a frame rate of 2 kiloframes per second, and a pitch of 7.8 mum x 7.8 mum for imaging of neural activity. The related circuit and system issues as well as process aspects are discussed. A mismatch-canceling calibration circuitry with current mode signal representation is used. Results from first biological experiments are presented, which prove full functionality of the chip.

引用

页码：2306 / 2317

页数：12

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