Ethanol hypersensitivity and olfactory discrimination defect in mice lacking a homolog of Drosophila neuralized

被引：50

作者：

Ruan, YL

Tecott, L

Jiang, MM

Jan, LY

Jan, YN ^{[1
]}

机构：

[1] Univ Calif San Francisco, Howard Hughes Med Inst, Dept Physiol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Howard Hughes Med Inst, Dept Biochem, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Dept Psychiat, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Ctr Neurobiol & Psychiat, San Francisco, CA 94143 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 2001年 / 98卷 / 17期

关键词：

D O I：

10.1073/pnas.171321098

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Neurogenic genes in the Notch receptor-mediated signaling pathway play important roles in neuronal cell fate specification as well as neuronal differentiation. The Drosophila neuralized gene is one of the neurogenic genes. We have cloned a mouse homolog of Drosophila neuralized, m-neu1, and found that the m-neu1 transcript is expressed in differentiated neurons. Mice deficient for m-neu1 are viable and morphologically normal, but exhibit specific defects in olfactory discrimination and hypersensitivity to ethanol. These findings reveal an essential role of m-neu1 in ensuring proper processing of certain information in the adult brain.

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页码：9907 / 9912

页数：6

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