A new approach to the facile synthesis of mono- and disubstituted quinazolin-4(3H)-ones under solvent-free conditions

被引：104

作者：

Salehi, P

Dabiri, M

Zolfigol, MA

Baghbanzadeh, M

机构：

[1] Shahid Beheshti Univ, Med Plants & Drugs Res Inst, Dept Phytochem, Tehran, Iran

[2] Shahid Beheshti Univ, Fac Sci, Dept Chem, Tehran, Iran

[3] Bu Ali Sina Univ, Fac Sci, Dept Chem, Hamadan, Iran

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 41期

关键词：

quinazolin-4(3H)-ones; silica sulfuric acid; catalysis; solvent free;

D O I：

10.1016/j.tetlet.2005.08.043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Quinazolin-4(3H)-one derivatives were synthesized successfully via a one-pot, three component reaction of isatoic anhydride and an orthoester with ammonium acetate or a primary amine catalyzed by silica sulfuric acid under solvent-free conditions. This is the first report on the synthesis of 2-substituted quinazolin-4(3H)-ones by this procedure. (c) 2005 Elsevier Ltd. All rights reserved.

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收藏

页码：7051 / 7053

页数：3

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