Screening strategies based on solubility and solution composition generate pharmaceutically acceptable cocrystals of carbamazepine

被引：306

作者：

Childs, Scott L. ^{[1
]}

Rodriguez-Hornedo, Nair ^{[2
]}

Reddy, L. Sreenivas ^{[2
]}

Jayasankar, Adivaraha ^{[2
]}

Maheshwari, Chinmay ^{[2
]}

McCausland, Linda ^{[1
]}

Shipplett, Rex ^{[1
]}

Stahly, Barbara C. ^{[1
]}

机构：

[1] Inc Aptuit Co, SSCI, W Lafayette, IN 47906 USA

[2] Univ Michigan, Dept Pharmaceut Sci, Ann Arbor, MI 48109 USA

来源：

CRYSTENGCOMM | 2008年 / 10卷 / 07期

关键词：

D O I：

10.1039/b715396a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Four different screening techniques were used to form cocrystals of carbamazepine containing pharmaceutically acceptable carboxylic acids. Twenty-seven unique solid phases utilizing eighteen carboxylic acid coformers were generated in the screening experiments. Cocrystal formation and stability in water is reported. Phase solubility diagrams and triangular phase diagrams are used to illustrate how saturation of the reactants leads to supersaturation of the cocrystal.

引用

收藏

页码：856 / 864

页数：9

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