Transcranial direct current stimulation improves recognition memory in Alzheimer disease

被引：342

作者：

Ferrucci, R. ^{[1
]}

Mameli, F. ^{[1
]}

Guidi, I. ^{[1
]}

Mrakic-Sposta, S. ^{[1
]}

Vergari, M. ^{[1
]}

Marceglia, S. ^{[1
]}

Cogiamanian, F. ^{[1
]}

Barbieri, S. ^{[1
]}

Scarpini, E. ^{[1
]}

Priori, A. ^{[1
]}

机构：

[1] Univ Milan, Osped Maggiore Policlin, Dept Neurol Sci, Fdn IRCCS, I-20122 Milan, Italy

来源：

NEUROLOGY | 2008年 / 71卷 / 07期

关键词：

D O I：

10.1212/01.wnl.0000317060.43722.a3

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Objective: To evaluate the cognitive effect of transcranial direct current stimulation (tDCS) over the temporoparietal areas in patients with Alzheimer disease (AD). Methods: In 10 patients with probable AD, we delivered anodal tDCS (AtDCS), cathodal tDCS (CtDCS), and sham tDCS (StDCS) over the temporoparietal areas in three sessions. In each session recognition memory and visual attention were tested at baseline (prestimulation) and 30 minutes after tDCS ended (poststimulation). Results: After AtDCS, accuracy of the word recognition memory task increased (prestimulation: 15.5 +/- 0.9, poststimulation: 17.9 +/- 0.8, p = 0.0068) whereas after CtDCS it decreased (15.8 +/- 0.6 vs 13.2 +/- 0.9, p = 0.011) and after StDCS it remained unchanged (16.3 +/- 0.7 vs 16.0 +/- 1.0, p = 0.75). tDCS left the visual attention-reaction times unchanged. Conclusion: Transcranial direct current stimulation (tDCS) delivered over the temporoparietal areas can specifically affect a recognition memory performance in patients with Alzheimer disease (AD). Because tDCS is simple, safe and inexpensive, our finding prompts studies using repeated tDCS, in conjunction with other therapeutic interventions for treating patients with AD.

引用

页码：493 / 498

页数：6

共 40 条

[1]

*APA, 1994, AM PSYCH ASS DIAGN S

[2] Non-synaptic mechanisms underlie the after-effects of cathodal transcutaneous direct current stimulation of the human brain [J].

Ardolino, G ;

Bossi, B ;

Barbieri, S ;

Priori, A .

JOURNAL OF PHYSIOLOGY-LONDON, 2005, 568 (02) :653-663

[3] Neural mechanisms of visual attention: Object-based selection of a region in space [J].

Arrington, CM ;

Carr, TH ;

Mayer, AR ;

Rao, SM .

JOURNAL OF COGNITIVE NEUROSCIENCE, 2000, 12 :106-117

[4]

Birks J, 2006, COCHRANE DB SYST REV, DOI [10.1002/14651858.CD001190.pub2, 10.1002/14651858.CD001190.pub3]

[5] A randomized, double-blind clinical trial on the efficacy of cortical direct current stimulation for the treatment of major depression [J].

Boggio, Paulo S. ;

Rigonatti, Sergio P. ;

Ribeiro, Rafael B. ;

Myczkowski, Martin L. ;

Nitsche, Michael A. ;

Pascual-Leone, Alvaro ;

Fregni, Felipe .

INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY, 2008, 11 (02) :249-254

[6]

Boggio PS, 2007, RESTOR NEUROL NEUROS, V25, P123

[7] Effects of transcranial direct current stimulation on working memory in patients with Parkinson's disease [J].

Boggio, Paulo S. ;

Ferrucci, Roberta ;

Rigonatti, Sergio P. ;

Covre, Priscila ;

Nitsche, Michael ;

Pascual-Leone, Alvaro ;

Fregni, Felipe .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 2006, 249 (01) :31-38

[8] When false recognition is unopposed by true recognition: Gist-based memory distortion in Alzheimer's disease [J].

Budson, AE ;

Daffner, KR ;

Desikan, R ;

Schacter, DL .

NEUROPSYCHOLOGY, 2000, 14 (02) :277-287

[9] Episodic memory in Alzheimer's disease: Separating response bias from discrimination [J].

Budson, Andrew E. ;

Wolk, David A. ;

Chong, Hyemi ;

Waring, Jill D. .

NEUROPSYCHOLOGIA, 2006, 44 (12) :2222-2232

[10] Memory performances in young, elderly, and very old healthy individuals versus patients with Alzheimer's disease: Evidence for discontinuity between normal and pathological aging [J].

Carlesimo, GA ;

Mauri, M ;

Graceffa, AMS ;

Fadda, L ;

Loasses, A ;

Lorusso, S ;

Caltagirone, C .

JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY, 1998, 20 (01) :14-29

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