8-OH-DPAT suppresses the induction of UP in brain slices of the rat lateral amygdala

被引：23

作者：

Pollandt, S ^{[1
]}

Drephal, C ^{[1
]}

Albrecht, D ^{[1
]}

机构：

[1] Humboldt Univ, Fac Med Charite, Johannes Muller Inst Physiol, D-10117 Berlin, Germany

来源：

NEUROREPORT | 2003年 / 14卷 / 06期

关键词：

lateral amygdala; LTP; 8-OH-DPAT; WAY; 100; 635;

D O I：

10.1097/00001756-200305060-00025

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The effect of 8-OH-DPAT on the induction of long-term potentiation (LTP) in the lateral nucleus of the amygdala was investigated using rat horizontal brain slice preparations. Bath-applied 8-OH-DPAT decreased the field potential amplitudes in a dose-dependent manner. In the lateral amygdala synapses, 8-OH-DPAT significantly suppressed the induction of LTP evoked by a weak theta burst stimulation. This suppression of LTP was also found using a concentration of 8-OH-DPAT, which did not influence the baseline activity significantly. The specific 5-HT1A receptor antagonist, WAY 100,635 blocked the inhibitory effect of B-OH-DPAT on the induction of LTR. The inhibitory effect of 5-HT1A receptor stimulation on amygdaloid neuronal plasticity suggests that the amygdala is a site for serotonin to exert its influence on memory of aversive events.

引用

页码：895 / 897

页数：3

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