Regulatory T cells control the development of allergic disease and asthma

被引：178

作者：

Umetsu, DT ^{[1
]}

Akbari, O ^{[1
]}

DeKruyff, RH ^{[1
]}

机构：

[1] Stanford Univ, Dept Pediat, Div Immunol & Allergy, Stanford, CA 94305 USA

来源：

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY | 2003年 / 112卷 / 03期

关键词：

T regulatory cells; T(H)2; asthma; allergy;

D O I：

10.1067/mai.2003.1717

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

The role of T(H)2 cells in the pathogenesis of allergy and asthma has been well described. However, the immunologic mechanisms that downmodulate and protect against the development of these disorders are poorly characterized. A spectrum of CD4(+) T cells, including T(H)1 cells, T(H)3 cells, regulatory T cells, CD25(+) T cells, and natural killer T cells might play a critical role in regulating these diseases and are discussed in this review.

引用

页码：480 / 487

页数：8

共 83 条

[1] Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen [J].

Akbari, O ;

DeKruyff, RH ;

Umetsu, DT .

NATURE IMMUNOLOGY, 2001, 2 (08) :725-731

[2]

Akbari O, 2002, NAT MED, V8, P1024, DOI 10.1038/nm745

[3] Essential role of NKT cells producing IL-4 and IL-13 in the development of allergen-induced airway hyperreactivity [J].

Akbari, O ;

Stock, P ;

Meyer, E ;

Kronenberg, M ;

Sidobre, S ;

Nakayama, T ;

Taniguchi, M ;

Grusby, MJ ;

DeKruyff, RH ;

Umetsu, DT .

NATURE MEDICINE, 2003, 9 (05) :582-588

[4] Mechanisms of disease: The effect of infections on susceptibility to autoimmune and allergic diseases [J].

Bach, JF .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (12) :911-920

[5] T cell regulation as a side effect of homeostasis and competition [J].

Barthlott, T ;

Kassiotis, G ;

Stockinger, B .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 197 (04) :451-460

[6]

Braun-Fahrländer C, 1999, CLIN EXP ALLERGY, V29, P28, DOI 10.1046/j.1365-2222.1999.00479.x

[7] Environmental exposure to endotoxin and its relation to asthma in school-age children [J].

Braun-Fahrländer, C ;

Riedler, J ;

Herz, U ;

Eder, W ;

Waser, M ;

Grize, L ;

Maisch, S ;

Carr, D ;

Gerlach, F ;

Bufe, A ;

Lauener, RP ;

Schierl, R ;

Renz, H ;

Nowak, D ;

von Mutius, E .

NEW ENGLAND JOURNAL OF MEDICINE, 2002, 347 (12) :869-877

[8] CD1d-mediated recognition of an α-galactosylceramide by natural killer T cells is highly conserved through mammalian evolution [J].

Brossay, L ;

Chioda, M ;

Burdin, N ;

Koezuka, Y ;

Casorati, G ;

Dellabona, P ;

Kronenberg, M .

JOURNAL OF EXPERIMENTAL MEDICINE, 1998, 188 (08) :1521-1528

[9] beta 2-microglobulin-dependent NK1.1(+) T cells are not essential for T helper cell 2 immune responses [J].

Brown, DR ;

Fowell, DJ ;

Corry, DB ;

Wynn, TA ;

Moskowitz, NH ;

Cheever, AW ;

Locksley, RM ;

Reiner, SL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (04) :1295-1304

[10] Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse [J].

Brunkow, ME ;

Jeffery, EW ;

Hjerrild, KA ;

Paeper, B ;

Clark, LB ;

Yasayko, SA ;

Wilkinson, JE ;

Galas, D ;

Ziegler, SF ;

Ramsdell, F .

NATURE GENETICS, 2001, 27 (01) :68-73

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