Retrovirus silencing by an epigenetic TRIM

被引：24

作者：

Ellis, James ^{[1
]}

Hotta, Akitsu

Rastegar, Mojgan

机构：

[1] SickKids Hosp, Dev & Stem Cell Biol Program, Toronto, ON, Canada

[2] Univ Toronto, Dept Mol & Med Genet, Toronto, ON M4X 1K9, Canada

来源：

CELL | 2007年 / 131卷 / 01期

关键词：

D O I：

10.1016/j.cell.2007.09.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Embryonic cells silence transcription by retroviruses, but how do they recognize virus DNA? In this issue, Wolf and Goff ( 2007) report that a TRIM28 corepressor complex binds to the retrovirus primer binding site. Epigenetic silencing of retrovirus transcription is accomplished by "writing" a dimethyl mark on lysine 9 of histone H3 that is read by the heterochromatin protein HP gamma.

引用

页码：13 / 14

页数：2

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