The application of probiotics in cancer

被引:63
作者
de Moreno de LeBlanc, Aleiandra
Matar, Chantal
Perdigon, Gabriela [1 ]
机构
[1] Consejo Nacl Invest Cient & Tecn, Ctr Referencia Lactobacilos, CERELA, San Miguel De Tucuman, Argentina
[2] Univ Moncton, Dept Chim Biochim, Moncton, NB E1A 3E9, Canada
[3] Univ Nacl Tucuman, Fac Bioquim Quim & Farm, Catedra Immunol, San Miguel De Tucuman, Argentina
关键词
probiotics; intestine; breast cancer; colon cancer;
D O I
10.1017/S0007114507839602
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Lactic acid bacteria (LAB) are present in many foods such as yoghurt and are frequently used as probiotics to favour some biological functions in the host. Many investigators have evaluated the therapeutic effects of yoghurt and LAB commonly used in yoghurt production against diseases such as cancer, infection, and gastrointestinal disorders. The increase of immune cell activity in the prevention of cancer by LAB consumption has also been described. Another possible explanation for the preventive effect of probiotics on carcinogenesis is their effect on other bacteria in the intestine. Probiotics may suppress the growth of bacteria that convert procarcinogens into carcinogens, thereby reducing the amount of carcinogens in the intestine. The present review is focused on two types of cancer in which milk fermented by LAB may show a beneficial effect: colon cancer and breast cancer
引用
收藏
页码:S105 / S110
页数:6
相关论文
共 23 条
[1]   The role of tumour-associated macrophages in tumour progression: implications for new anticancer therapies [J].
Bingle, L ;
Brown, NJ ;
Lewis, CE .
JOURNAL OF PATHOLOGY, 2002, 196 (03) :254-265
[2]   The role of nitric oxide in innate immunity [J].
Bogdan, CT ;
Röllinghoff, M ;
Diefenbach, A .
IMMUNOLOGICAL REVIEWS, 2000, 173 :17-26
[3]   Let's go mucosal: communication on slippery ground [J].
Brandtzaeg, P ;
Pabst, R .
TRENDS IN IMMUNOLOGY, 2004, 25 (11) :570-577
[4]   Effects of milk fermented by Lactobacillus helveticus R389 on immune cells associated to mammary glands in normal and a breast cancer model [J].
de LeBlanc, AD ;
Matar, C ;
Thériault, C ;
Perdigón, G .
IMMUNOBIOLOGY, 2005, 210 (05) :349-358
[5]   Effects of milk fermented by Lactobacillus helveticus R389 on a murine breast cancer model [J].
de LeBlanc, AD ;
Matar, C ;
LeBlanc, N ;
Perdigón, G .
BREAST CANCER RESEARCH, 2005, 7 (04) :R477-R486
[6]  
de Moreno de LeBlanc A., 2004, EUR J INFLAMM, V2, P21, DOI DOI 10.1177/1721727X0400200104
[7]  
DELEBLANC AD, 2004, MED SCI MONIT, V10
[8]  
Feghali Carol A., 1997, Frontiers in Bioscience (online), V2, pD12
[9]   Human γδ T cells:: a nonredundant system in the immune-surveillance against cancer [J].
Ferrarini, M ;
Ferrero, E ;
Dagna, L ;
Poggi, A ;
Zocchi, MR .
TRENDS IN IMMUNOLOGY, 2002, 23 (01) :14-18
[10]  
FULTON AM, 1984, CANCER RES, V44, P2416