The application of probiotics in cancer

被引：63

作者：

de Moreno de LeBlanc, Aleiandra

Matar, Chantal

Perdigon, Gabriela ^{[1
]}

机构：

[1] Consejo Nacl Invest Cient & Tecn, Ctr Referencia Lactobacilos, CERELA, San Miguel De Tucuman, Argentina

[2] Univ Moncton, Dept Chim Biochim, Moncton, NB E1A 3E9, Canada

[3] Univ Nacl Tucuman, Fac Bioquim Quim & Farm, Catedra Immunol, San Miguel De Tucuman, Argentina

来源：

BRITISH JOURNAL OF NUTRITION | 2007年 / 98卷

关键词：

probiotics; intestine; breast cancer; colon cancer;

D O I：

10.1017/S0007114507839602

中图分类号：

R15 [营养卫生、食品卫生]; TS201 [基础科学];

学科分类号：

100403 ;

摘要：

Lactic acid bacteria (LAB) are present in many foods such as yoghurt and are frequently used as probiotics to favour some biological functions in the host. Many investigators have evaluated the therapeutic effects of yoghurt and LAB commonly used in yoghurt production against diseases such as cancer, infection, and gastrointestinal disorders. The increase of immune cell activity in the prevention of cancer by LAB consumption has also been described. Another possible explanation for the preventive effect of probiotics on carcinogenesis is their effect on other bacteria in the intestine. Probiotics may suppress the growth of bacteria that convert procarcinogens into carcinogens, thereby reducing the amount of carcinogens in the intestine. The present review is focused on two types of cancer in which milk fermented by LAB may show a beneficial effect: colon cancer and breast cancer

引用

页码：S105 / S110

页数：6

共 23 条

[11] IMMUNOPEROXIDASE STUDY OF THE SECRETORY IMMUNOGLOBULIN SYSTEM AND LYSOZYME IN NORMAL AND DISEASED GASTRIC-MUCOSA [J].

ISAACSON, P .

GUT, 1982, 23 (07) :578-588

[12] INDOMETHACIN THERAPY ABROGATES THE PROSTAGLANDIN-MEDIATED SUPPRESSION OF NATURAL-KILLER ACTIVITY IN TUMOR-BEARING MICE AND PREVENTS TUMOR-METASTASIS [J].

LALA, PK ;

PARHAR, RS ;

SINGH, P .

CELLULAR IMMUNOLOGY, 1986, 99 (01) :108-118

[13] Immunomodulating effects of peptidic fractions issued from milk fermented with Lactobacillus helveticus [J].

LeBlanc, JG ;

Matar, C ;

Valdéz, JC ;

LeBlanc, J ;

Perdigon, G .

JOURNAL OF DAIRY SCIENCE, 2002, 85 (11) :2733-2742

[14]

Matar C, 2003, FUN FO NUTR SERIES, P177

[15] Immunomodulating effects of milks fermented by Lactobacillus helveticus and its non-proteolytic variant [J].

Matar, C ;

Valdez, JC ;

Medina, M ;

Rachid, M ;

Perdigon, G .

JOURNAL OF DAIRY RESEARCH, 2001, 68 (04) :601-609

[16] The effect of milk fermentation by Lactobacillus helveticus on the release of peptides during in vitro digestion [J].

Matar, C ;

Amiot, J ;

Savoie, L ;

Goulet, J .

JOURNAL OF DAIRY SCIENCE, 1996, 79 (06) :971-979

[17] Antitumour activity of yogurt:: study of possible immune mechanisms [J].

Perdigón, G ;

Valdez, JC ;

Rachid, M .

JOURNAL OF DAIRY RESEARCH, 1998, 65 (01) :129-138

[18] Role of yoghurt in the prevention of colon cancer [J].

Perdigón, G ;

de LeBlanc, AD ;

Valdez, J ;

Rachid, M .

EUROPEAN JOURNAL OF CLINICAL NUTRITION, 2002, 56 (Suppl 3) :S65-S68

[19]

PRESCOTT SM, 2000, BIOCHIM BIOPHYS ACTA, V1470, P69, DOI [10.1016/s0304-419x(00)00006-8), DOI 10.1016/S0304-419X(00)00006-8]

[20] The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer [J].

Purohit, A ;

Newman, SP ;

Reed, MJ .

BREAST CANCER RESEARCH, 2002, 4 (02) :65-69

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