The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer

被引：193

作者：

Purohit, A ^{[1
]}

Newman, SP ^{[1
]}

Reed, MJ ^{[1
]}

机构：

[1] St Marys Hosp, Imperial Coll, Fac Med, London W2 1NY, England

来源：

BREAST CANCER RESEARCH | 2002年 / 4卷 / 02期

关键词：

aromatase; breast cancer; cytokines; estrogens; estrone 17 beta-hydroxysteroid dehydrogenase; estrone sulfatase;

D O I：

10.1186/bcr425

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytokines, such as IL-6 and tumor necrosis factor (TNF)-alpha, have an important role in regulating estrogen synthesis in peripheral tissues, including normal and malignant breast tissues. The activities of the aromatase, estradiol 17beta-hydroxysteroid dehydrogenase and estrone sulfatase are all increased by IL-6 and TNF-alpha. Prostaglandin E-2 may also be an important regulator of aromatase activity in breast tumors. Macrophages and lymphocytes, which invade many breast tumors, are thought to be an important source of factors that can stimulate estrogen synthesis in malignant breast tissues. The coordinated stimulation of the activities of the enzymes that are involved in estrogen synthesis offers an explanation for the high concentrations of estrogens that are present in breast tumors.

引用

页码：65 / 69

页数：5

共 40 条

[1] AROMATIZATION OF ANDROSTENEDIONE BY HUMAN ADIPOSE-TISSUE STROMAL CELLS IN MONOLAYER-CULTURE [J].

ACKERMAN, GE ;

SMITH, ME ;

MENDELSON, CR ;

MACDONALD, PC ;

SIMPSON, ER .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1981, 53 (02) :412-417

[2] INTERLEUKIN-6 IS SECRETED BY BREAST FIBROBLASTS AND STIMULATES 17-BETA-ESTRADIOL OXIDOREDUCTASE ACTIVITY OF MCF-7 CELLS - POSSIBLE PARACRINE REGULATION OF BREAST 17-BETA-ESTRADIOL LEVELS [J].

ADAMS, EF ;

RAFFERTY, B ;

WHITE, MC .

INTERNATIONAL JOURNAL OF CANCER, 1991, 49 (01) :118-121

[3] Use of alternative promoters to express the aromatase cytochrome P450 (CYP19) gene in breast adipose tissues of cancer-free and breast cancer patients [J].

Agarwal, VR ;

Bulun, SE ;

Leitch, M ;

Rohrich, R ;

Simpson, ER .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1996, 81 (11) :3843-3849

[4] ON THE SIGNIFICANCE OF INSITU PRODUCTION OF ESTROGENS IN HUMAN BREAST-CANCER TISSUE [J].

BLANKENSTEIN, MA ;

MAITIMUSMEELE, I ;

DONKER, GH ;

DAROSZEWSKI, J ;

MILEWICZ, A ;

THIJSSEN, JHH .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1992, 41 (3-8) :891-896

[5] THE RELATIONSHIP BETWEEN 17-BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY AND ESTROGEN CONCENTRATIONS IN HUMAN-BREAST TUMORS AND IN NORMAL BREAST-TISSUE [J].

BONNEY, RC ;

REED, MJ ;

DAVIDSON, K ;

BERANEK, PA ;

JAMES, VHT .

CLINICAL ENDOCRINOLOGY, 1983, 19 (06) :727-739

[6] ADVERSE LIFE EVENTS AND BREAST-CANCER - CASE-CONTROL STUDY [J].

CHEN, CC ;

DAVID, AS ;

NUNNERLEY, H ;

MICHELL, M ;

DAWSON, JL ;

BERRY, H ;

DOBBS, J ;

FAHY, T .

BRITISH MEDICAL JOURNAL, 1995, 311 (7019) :1527-1530

[7] REGULATION OF MURINE LYMPHOKINE PRODUCTION INVIVO .3. THE LYMPHOID-TISSUE MICROENVIRONMENT EXERTS REGULATORY INFLUENCES OVER T-HELPER CELL-FUNCTION [J].

DAYNES, RA ;

ARANEO, BA ;

DOWELL, TA ;

HUANG, K ;

DUDLEY, D .

JOURNAL OF EXPERIMENTAL MEDICINE, 1990, 171 (04) :979-996

[8] THE INTERACTION OF CYTOKINES IN REGULATING ESTRADIOL 17-BETA-HYDROXYSTEROID DEHYDROGENASE-ACTIVITY IN MCF-7 CELLS [J].

DUNCAN, LJ ;

COLDHAM, NG ;

REED, MJ .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 1994, 49 (01) :63-68

[9]

ESTEBAN JM, 1992, AM J PATHOL, V140, P337

[10] TISSUE-SPECIFIC EXPRESSION OF THE HUMAN AROMATASE CYTOCHROME-P-450 GENE BY ALTERNATIVE USE OF MULTIPLE EXONS-1 AND PROMOTERS, AND SWITCHING OF TISSUE-SPECIFIC EXONS-1 IN CARCINOGENESIS [J].

HARADA, N ;

UTSUMI, T ;

TAKAGI, Y .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (23) :11312-11316

← 1 2 3 4 →