The role of cytokines in regulating estrogen synthesis: implications for the etiology of breast cancer

被引：193

作者：

Purohit, A ^{[1
]}

Newman, SP ^{[1
]}

Reed, MJ ^{[1
]}

机构：

[1] St Marys Hosp, Imperial Coll, Fac Med, London W2 1NY, England

来源：

BREAST CANCER RESEARCH | 2002年 / 4卷 / 02期

关键词：

aromatase; breast cancer; cytokines; estrogens; estrone 17 beta-hydroxysteroid dehydrogenase; estrone sulfatase;

D O I：

10.1186/bcr425

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Cytokines, such as IL-6 and tumor necrosis factor (TNF)-alpha, have an important role in regulating estrogen synthesis in peripheral tissues, including normal and malignant breast tissues. The activities of the aromatase, estradiol 17beta-hydroxysteroid dehydrogenase and estrone sulfatase are all increased by IL-6 and TNF-alpha. Prostaglandin E-2 may also be an important regulator of aromatase activity in breast tumors. Macrophages and lymphocytes, which invade many breast tumors, are thought to be an important source of factors that can stimulate estrogen synthesis in malignant breast tissues. The coordinated stimulation of the activities of the enzymes that are involved in estrogen synthesis offers an explanation for the high concentrations of estrogens that are present in breast tumors.

引用

页码：65 / 69

页数：5

共 40 条

[31] IL-6SR - RELEASE FROM MCF-7 BREAST-CANCER CELLS AND ROLE IN REGULATING PERIPHERAL ESTROGEN SYNTHESIS [J].

SINGH, A ;

PUROHIT, A ;

WANG, DY ;

DUNCAN, LJ ;

GHILCHIK, MW ;

REED, MJ .

JOURNAL OF ENDOCRINOLOGY, 1995, 147 (02) :R9-R12

[32]

Singh A, 1997, J STEROID BIOCHEM, V61, P185

[33] SYNERGISTIC INTERACTION OF GROWTH-FACTORS AND ALBUMIN IN REGULATING ESTRADIOL SYNTHESIS IN BREAST-CANCER CELLS [J].

SINGH, A ;

BLENCH, I ;

MORRIS, HR ;

SAVOY, LA ;

REED, MJ .

MOLECULAR AND CELLULAR ENDOCRINOLOGY, 1992, 85 (03) :165-173

[34] INCIDENCE OF DE-NOVO BREAST-CANCER IN WOMEN CHRONICALLY IMMUNOSUPPRESSED AFTER ORGAN-TRANSPLANTATION [J].

STEWART, T ;

TSAI, SJ ;

GRAYSON, H ;

HENDERSON, R ;

OPELZ, G .

LANCET, 1995, 346 (8978) :796-798

[35]

Utsumi T, 1999, CANCER RES, V59, P377

[36] Elevated steroid sulfatase expression in breast cancers [J].

Utsumi, T ;

Yoshimura, N ;

Takeuchi, S ;

Maruta, H ;

Maeda, K ;

Harada, N .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2000, 73 (3-4) :141-145

[37] INCREASE OF PLASMA IL-6 CONCENTRATION WITH AGE IN HEALTHY-SUBJECTS [J].

WEI, J ;

XU, HM ;

DAVIES, JL ;

HEMMINGS, GP .

LIFE SCIENCES, 1992, 51 (25) :1953-1956

[38] CHARACTERIZATION OF THE SEQUENCES OF THE HUMAN CYP19 (AROMATASE) GENE THAT MEDIATE REGULATION BY GLUCOCORTICOIDS IN ADIPOSE STROMAL CELLS AND FETAL HEPATOCYTES [J].

ZHAO, Y ;

MENDELSON, CR ;

SIMPSON, ER .

MOLECULAR ENDOCRINOLOGY, 1995, 9 (03) :340-349

[39] AROMATASE P450 GENE-EXPRESSION IN HUMAN ADIPOSE-TISSUE - ROLE OF A JAK/STAT PATHWAY IN REGULATION OF THE ADIPOSE-SPECIFIC PROMOTER [J].

ZHAO, Y ;

NICHOLS, JE ;

BULUN, SE ;

MENDELSON, CR ;

SIMPSON, ER .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (27) :16449-16457

[40] Estrogen biosynthesis proximal to a breast tumor is stimulated by PGE(2) via cyclic AMP, reading to activation of promoter II of the CYP19 (aromatase) gene [J].

Zhao, Y ;

Agarwal, VR ;

Mendelson, CR ;

Simpson, ER .

ENDOCRINOLOGY, 1996, 137 (12) :5739-5742

← 1 2 3 4 →