NLR functions beyond pathogen recognition

被引：166

作者：

Kufer, Thomas A. ^{[3
]}

Sansonetti, Philippe J. ^{[1
,2
,4
]}

机构：

[1] Inst Pasteur, Unite Pathogenie Microbienne Mol, Paris, France

[2] Inst Pasteur, INSERM, U786, F-75724 Paris, France

[3] Univ Cologne, Inst Med Microbiol Immunol & Hyg, Cologne, Germany

[4] Coll France, Chaire Microbiol & Malad Infect, F-75231 Paris, France

来源：

NATURE IMMUNOLOGY | 2011年 / 12卷 / 02期

关键词：

NF-KAPPA-B; INDUCIBLE INFLAMMATORY MEDIATOR; AUTOIMMUNE ADDISONS-DISEASE; STEM-CELL TRANSPLANTATION; GENE-EXPRESSION PATTERNS; GENOME-WIDE ASSOCIATION; INNATE IMMUNE RECEPTORS; NECROSIS-FACTOR-ALPHA; FAMILY-MEMBER NLRC5; NOD-LIKE RECEPTORS;

D O I：

10.1038/ni.1985

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The last 10 years have witnessed the identification of a new class of intracellular pattern-recognition molecules-the nucleotide-binding domain and leucine-rich repeat-containing family (NLR). Members of this family garnered interest as pattern-recognition receptors able to trigger inflammatory responses against pathogens. Many studies support a pathogen-recognition function for human NLR proteins and shed light on their role in the broader control of adaptive immunity and various disease states. Other evidence suggests that NLRs function in processes unrelated to pathogen detection. Here we discuss recent advances in our understanding of the biology of the human NLR proteins and their non-pathogen-recognition function in tissue homeostasis, apoptosis, graft-versus-host disease and early development.

引用

页码：121 / 128

页数：8

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