Boronic acids in medicinal chemistry: anticancer, antibacterial and antiviral applications

被引：282

作者：

Trippier, Paul C. ^{[1
]}

McGuigan, Christopher ^{[1
]}

机构：

[1] Cardiff Univ, Welsh Sch Pharm, Cardiff CF10 3NB, S Glam, Wales

来源：

MEDCHEMCOMM | 2010年 / 1卷 / 03期

关键词：

ACTIVE PROTEASOME INHIBITOR; STATE ANALOG INHIBITORS; ALPHA-LYTIC PROTEASE; BIOLOGICAL EVALUATION; ANTIFUNGAL ACTIVITY; CRYSTAL-STRUCTURE; CELL-GROWTH; IN-VITRO; POTENT; IDENTIFICATION;

D O I：

10.1039/c0md00119h

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In 2003, bortezomib, a first-in-class therapeutic, gained approval from the US Federal Drug Administration for the treatment of relapsed multiple myeloma and mantle cell lymphoma. Approval in the UK, for multiple myeloma, followed in 2006. Bortezomib contains a boronic acid, a functional group that has become increasingly more commonplace within the medicinal chemistry literature. The introduction of this drug has sparked a renewed interest in the investigation of boronic acids as drugs for a wide range of diseases. This review will guide the read through the most recent developments in this field, by considering in turn, the biological target's amenable to the action of boronic acids.

引用

页码：183 / 198

页数：16

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