Quinolone alkaloids with nitric oxide production inhibitory activity from Orixa japonica

被引：80

作者：

Ito, C

Itoigawa, M ^{[1
]}

Furukawa, A

Hirano, T

Murata, T

Kaneda, N

Hisada, Y

Okuda, K

Furukawa, H

机构：

[1] Meijo Univ, Dept Med Chem, Fac Pharm, Nagoya, Aichi 4688503, Japan

[2] Tokai Gakuen Univ, Nagoya, Aichi 4688514, Japan

[3] Meijo Univ, Dept Analyt Neurobiol, Fac Pharm, Nagoya, Aichi 4688503, Japan

[4] Meijo Univ, Dept Pharmacognosy, Fac Pharm, Nagoya, Aichi 4688503, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2004年 / 67卷 / 11期

关键词：

D O I：

10.1021/np0401462

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Four new quinolone alkaloids, orixalone A (1), B (2), C (3), and D (4), together with 12 known compounds were isolated from the stems of Orixa japonica. Orixalone A (1) inhibited nitric oxide production in murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma and lipopolysaccharide.

引用

页码：1800 / 1803

页数：4

共 19 条

[1] RESOLUTION OF PRENYL BROMOHYDRIN ESTERS AND DERIVATIVES - SYNTHESIS OF THE QUINOLINE ALKALOID (+)-(R)-LUNACRIDINE AND (-)-(S)-LUNACRIDINE [J].

BARR, SA ;

BOYD, DR ;

SHARMA, ND ;

EVANS, TA ;

MALONE, JF ;

MEHTA, VD .

TETRAHEDRON, 1994, 50 (38) :11219-11234

[2] Carbazole alkaloids from roots of Glycosmis arborea [J].

Chakravarty, AK ;

Sarkar, T ;

Masuda, K ;

Shiojima, K .

PHYTOCHEMISTRY, 1999, 50 (07) :1263-1266

[3] QUINOLINE ALKALOIDS .12. ALKALOIDS AND COUMARINS OF ORIXAJAPONICA THUNB - IDENTIFICATION OF A NEW QUINOLINE ALKOLOID, ORIXINONE [J].

DONNELLY, WJ ;

GRUNDON, MF .

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1972, (16) :2116-&

[4] (+)-3'-O-acetylisopteleflorine, a quinoline alkaloid from Orixa japonica [J].

Funayama, S ;

Murata, K ;

Nozoe, S .

PHYTOCHEMISTRY, 1996, 41 (04) :1231-1233

[5] QUINOLINE ALKALOIDS FROM ORIXA-JAPONICA [J].

FUNAYAMA, S ;

MURATA, K ;

NOZOE, S .

PHYTOCHEMISTRY, 1994, 36 (02) :525-528

[6]

Funayama S, 1996, CHEM PHARM BULL, V44, P1885

[7]

*HOK CO LTD, 2002, NEWL REV ILL MED PLA, P250

[8]

ITO C, 1988, CHEM PHARM BULL, V36, P3805, DOI 10.1248/cpb.36.3805

[9] Chemical constituents of Glycosmis arborea:: Three new carbazole alkaloids and their biological activity [J].

Ito, C ;

Itoigawa, M ;

Sato, A ;

Hasan, CM ;

Rashid, MA ;

Tokuda, H ;

Mukainaka, T ;

Nishino, H ;

Furukawa, H .

JOURNAL OF NATURAL PRODUCTS, 2004, 67 (09) :1488-1491

[10] Constituents of Boronia pinnata [J].

Ito, C ;

Itoigawa, M ;

Otsuka, T ;

Tokuda, H ;

Nishino, H ;

Furukawa, H .

JOURNAL OF NATURAL PRODUCTS, 2000, 63 (10) :1344-1348

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