Constituents of Boronia pinnata

被引：74

作者：

Ito, C

Itoigawa, M ^{[1
]}

Otsuka, T

Tokuda, H

Nishino, H

Furukawa, H

机构：

[1] Tokai Gakuen Univ, Aichi 4700207, Japan

[2] Meijo Univ, Fac Pharm, Tempaku Ku, Nagoya, Aichi 4688503, Japan

[3] Kyoto Prefectural Univ Med, Dept Biochem, Kamigyo Ku, Kyoto 6020841, Japan

来源：

JOURNAL OF NATURAL PRODUCTS | 2000年 / 63卷 / 10期

关键词：

D O I：

10.1021/np0000318

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A novel quinolone, pinolinone (1); seven new phenylpropanoids, boropinols A (2), B (3), C (4), boropinals A (5), B (6), C (7), and boropinic acid (8); and a new lignan, boropinan (9), were isolated from the roots of Boronia pinnata, and their structures were elucidated by NMR and MS analyses. In a search for novel cancer chemopreventive agents (antitumor-promoters), we screened 10 compounds isolated from the plant for their inhibitory effects on Epstein-Barr virus early antigen (EBV-EA) activation induced by 12-O-tetradecanoylphorbol-13-acetate in Raji cells. Boropinic acid (8) and 4'-hydroxy-3'-prenylcinnamaldehyde were observed to significantly inhibit the EBV-EA activation.

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页码：1344 / 1348

页数：5

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