Biology using engineering tools The negative feedback amplifier

被引：16

作者：

Birtwistle, Marc R. ^{[1
]}

Kolch, Walter ^{[1
]}

机构：

[1] Univ Coll Dublin, Dublin 2, Ireland

来源：

CELL CYCLE | 2011年 / 10卷 / 13期

基金：

爱尔兰科学基金会;

关键词：

negative feedback; signal transduction; quantitative modeling; mitogen activated protein kinase; spatiotemporal dynamics; ACTIVATED PROTEIN-KINASE; SIGNAL-REGULATED KINASE; EPIDERMAL-GROWTH-FACTOR; CELL FATE DECISIONS; EGF RECEPTOR; PHOSPHORYLATION SITES; DIFFERENTIAL REGULATION; TRANSDUCTION PATHWAYS; DOWN-REGULATION; ERBB NETWORK;

D O I：

10.4161/cc.10.13.16245

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Negative feedback is a ubiquitous feature of biological networks. Recent work from Sturm and colleagues(1) presents experimental evidence that biological negative feedback can serve the same function as it does for engineered systems: robustness to perturbations within the feedback loop. Such behavior has important implications for how to attack deregulated signaling networks containing negative feedback in diseases as cancer.

引用

收藏

页码：2069 / 2076

页数：8

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