TCMID 2.0: a comprehensive resource for TCM

被引：435

作者：

Huang, Lin ^{[1
]}

Xie, Duoli ^{[1
]}

Yu, Yiran ^{[1
]}

Liu, Huanlong ^{[2
,3
]}

Shi, Yan ^{[2
,3
]}

Shi, Tieliu ^{[2
,3
]}

Wen, Chengping ^{[1
]}

机构：

[1] Zhejiang Chinese Med Univ, TCM Clin Basis Inst, Hangzhou 310000, Zhejiang, Peoples R China

[2] East China Normal Univ, Inst Biomed Sci, Shanghai Key Lab Regulatory Biol, Ctr Bioinformat & Computat Biol, Shanghai 200241, Peoples R China

[3] East China Normal Univ, Sch Life Sci, Shanghai 200241, Peoples R China

来源：

NUCLEIC ACIDS RESEARCH | 2018年 / 46卷 / D1期

基金：

中国国家自然科学基金; 国家高技术研究发展计划(863计划);

关键词：

TRADITIONAL CHINESE MEDICINE; DATABASE; MECHANISMS; TANG;

D O I：

10.1093/nar/gkx1028

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

As a traditional medical intervention in Asia and a complementary and alternative medicine in western countries, Traditional Chinese Medicine (TCM) is capturing worldwide attention in life science field. Traditional Chinese Medicine Integrated Database (TCMID), which was originally launched in 2013, was a comprehensive database aiming at TCM's modernization and standardization. It has been highly recognized among pharmacologists and scholars in TCM researches. The latest release, TCMID 2.0 (http://www.megabionet.org/tcmid/), replenished the preceding database with 18 203 herbal ingredients, 15 prescriptions, 82 related targets, 1356 drugs, 842 diseases and numerous new connections between them. Considering that chemical changes might take place in decocting process of prescriptions, which may result in new ingredients, new data containing the prescription ingredients was collected in current version. In addition, 778 herbal mass spectrometry (MS) spectra related to 170 herbs were appended to show the variation of herbal quality in different origin and distinguish genuinemedicinal materials from common ones while 3895 MS spectra of 729 ingredients were added as the supplementary materials of component identification. With the significant increase of data, TCMID 2.0 will further facilitate TCM's modernization and enhance the exploration of underlying biological processes that are response to the diverse pharmacologic actions of TCM.

引用

页码：D1117 / D1120

页数：4

共 20 条

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Agarwala R, 2018, NUCLEIC ACIDS RES, V46, pD8, DOI [10.1093/nar/gks1189, 10.1093/nar/gkx1095, 10.1093/nar/gkq1172]

[2]

Baxevanis Andreas D, 2012, Curr Protoc Hum Genet, VChapter 9, DOI [10.1002/0471250953.bi0102s27, 10.1002/0471142905.hg0913s73]

[3]

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