A Hermetic Wireless Subretinal Neurostimulator for Vision Prostheses

被引:78
作者
Kelly, Shawn K. [1 ,2 ]
Shire, Douglas B. [1 ,3 ]
Chen, Jinghua [4 ,5 ]
Doyle, Patrick [1 ,2 ]
Gingerich, Marcus D. [1 ,3 ]
Cogan, Stuart F. [6 ]
Drohan, William A. [1 ,2 ]
Behan, Sonny [7 ]
Theogarajan, Luke [8 ]
Wyatt, John L. [2 ]
Rizzo, Joseph F., III [1 ,4 ,5 ]
机构
[1] VA Boston Healthcare Syst, Ctr Innovat Visual Rehabil, Boston, MA 02130 USA
[2] MIT, Elect Res Lab, Cambridge, MA 02139 USA
[3] Cornell Univ, Ithaca, NY 14853 USA
[4] Harvard Univ, Sch Med, Dept Ophthalmol, Boston, MA 02114 USA
[5] Massachusetts Eye & Ear Infirm, Boston, MA 02114 USA
[6] EIC Labs Inc, Norwood, MA 02062 USA
[7] Sonny Behan Consulting, Atlanta, GA 30096 USA
[8] Univ Calif Santa Barbara, Santa Barbara, CA 92106 USA
基金
美国国家科学基金会;
关键词
Biomedical electrodes; integrated circuit design; iridium oxide; neuromuscular stimulation; retinal implant; retinal prosthesis; telemetry; CHARGE-INJECTION LIMITS; IRIDIUM OXIDE AIROF; ELECTRICAL-STIMULATION; HUMAN RETINA; IMPLANTATION;
D O I
10.1109/TBME.2011.2165713
中图分类号
R318 [生物医学工程];
学科分类号
100103 [病原生物学];
摘要
A miniaturized, hermetically encased, wirelessly operated retinal prosthesis has been developed for preclinical studies in the Yucatan minipig, and includes several design improvements over our previously reported device. The prosthesis attaches conformally to the outside of the eye and electrically drives a microfabricated thin-film polyimide array of sputtered iridium oxide film electrodes. This array is implanted into the subretinal space using a customized ab externo surgical technique. The implanted device includes a hermetic titanium case containing a 15-channel stimulator chip and discrete circuit components. Feedthroughs in the case connect the stimulator chip to secondary power and data receiving coils on the eye and to the electrode array under the retina. Long-term in vitro pulse testing of the electrodes projected a lifetime consistent with typical devices in industry. The final assembly was tested in vitro to verify wireless operation of the system in physiological saline using a custom RF transmitter and primary coils. Stimulation pulse strength, duration, and frequency were programmed wirelessly from a Peripheral Component Interconnect eXtensions for Instrumentation (PXI) computer. Operation of the retinal implant has been verified in two pigs for up to five and a half months by detecting stimulus artifacts generated by the implanted device.
引用
收藏
页码:3197 / 3205
页数:9
相关论文
共 28 条
[1]
SENSATIONS PRODUCED BY ELECTRICAL STIMULATION OF VISUAL CORTEX [J].
BRINDLEY, GS ;
LEWIN, WS .
JOURNAL OF PHYSIOLOGY-LONDON, 1968, 196 (02) :479-&
[2]
Chen J, 2010, INVEST OPHTH VIS SCI, V51
[3]
Extraction of a Chronically Implanted, Microfabricated, Subretinal Electrode Array [J].
Chen, Jinghua ;
Shah, Hassan A. ;
Herbert, Charles ;
Loewenstein, John I. ;
Rizzo, Joseph F., III .
OPHTHALMIC RESEARCH, 2009, 42 (03) :128-137
[4]
In vitro comparison of the charge-injection limits of activated iridium oxide (AIROF) and platinum-iridium microelectrodes [J].
Cogan, SF ;
Troyk, PR ;
Ehrlich, J ;
Plante, TD .
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING, 2005, 52 (09) :1612-1614
[5]
The influence of electrolyte composition on the in vitro charge-injection limits of activated iridium oxide (AIROF) stimulation electrodes [J].
Cogan, Stuart F. ;
Troyk, Philip R. ;
Ehrlich, Julia ;
Gasbarro, Christina M. ;
Plante, Timothy D. .
JOURNAL OF NEURAL ENGINEERING, 2007, 4 (02) :79-86
[6]
Stimulation via a subretinally placed prosthetic elicits central activity and induces a trophic effect on visual responses [J].
DeMarco, Paul J., Jr. ;
Yarbrough, Gary L. ;
Yee, Christopher W. ;
McLean, George Y. ;
Sagdullaev, Botir T. ;
Ball, Sherry L. ;
McCall, Maureen A. .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2007, 48 (02) :916-926
[7]
BRAILLE READING BY A BLIND VOLUNTEER BY VISUAL-CORTEX STIMULATION [J].
DOBELLE, WH ;
MLADEJOVSKY, MG ;
EVANS, JR ;
ROBERTS, TS ;
GIRVIN, JP .
NATURE, 1976, 259 (5539) :111-112
[8]
Friedman DS, 2004, ARCH OPHTHALMOL-CHIC, V122, P564
[9]
Experimental implantation of epiretinal retina implants (EPI-RET) with an IOL-type receiver unit [J].
Gerding, H. ;
Benner, F. P. ;
Taneri, S. .
JOURNAL OF NEURAL ENGINEERING, 2007, 4 (01) :S38-S49
[10]
Hornig R., 2007, Artificial Sight: Basic Research, Biomedical Engineering, and Clinical Advances, P111