An efficient two-step synthesis of jensenone isolated from Eucalyptus jensenii.: Synthesis of analogues and evaluation as antioxidants

A phloroglucinol derivative, jensenone ( 1) isolated from leaves of Eucalyptus jensenii has been synthesized for the first time through a short and efficient two-step procedure starting from commercially available phloroglucinol. The methodology provides a simplified route to introduce diformyl moiety for synthesis of biologically active formylated phloroglucinol compounds such as antimalarial robustadials, cancer chemopreventive euglobals, and antifouling sideroxylonals. Several analogues of jensenone have also been synthesized and evaluated for antioxidant capacity.