A matrix associated region localizes the human SOCS-1 gene to chromosome 16p13.13

被引：14

作者：

Kramer, JA

Adams, MD

Singh, GB

Doggett, NA

Krawetz, SA

机构：

[1] Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Dept Obstet & Gynecol, Allen Park, MI 48101 USA

[2] Oakland Univ, Dept Comp Sci & Engn, Rochester, MI 48309 USA

[3] Univ Calif Los Alamos Natl Lab, Ctr Human Genome Studies, Los Alamos, NM 87545 USA

来源：

SOMATIC CELL AND MOLECULAR GENETICS | 1998年 / 24卷 / 02期

关键词：

D O I：

10.1023/B:SCAM.0000007115.58601.87

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The MarFinder algorithm was applied to a newly sequenced segment of 16p13,13 abutting the 3' end of the human PRM1 --> PRM2 --> TNP2 locus. A candidate region of matrix attached was identified. Subsequent biophysical analysis showed that this region was attached to the somatic nuclear matrix. Nucleotide sequence analysis also revealed the presence of a CpG island. Data base queries showed that this region contained the SOCS-1 gene. Thus, the SOCS-1 gene is bounded by a somatic MAR and is just 3' of the spermatid-expressed PRM1 --> PRM2 --> TNP2 domain at position 16p13.13.

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收藏

页码：131 / 133

页数：3

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