Combination therapy of fasudil hydrochloride and ozagrel sodium for cerebral vasospasm following aneurysmal subarachnoid hemorrhage

被引：29

作者：

Nakashima, S ^{[1
]}

Tabuchi, K ^{[1
]}

Shimokawa, S ^{[1
]}

Fukuyama, K ^{[1
]}

Mineta, T ^{[1
]}

Abe, M ^{[1
]}

机构：

[1] Saga Med Sch, Dept Neurosurg, Saga, Japan

来源：

NEUROLOGIA MEDICO-CHIRURGICA | 1998年 / 38卷 / 12期

关键词：

subarachnoid hemorrhage; vasospasm; fasudil hydrochloride; ozagrel sodium; combination therapy;

D O I：

10.2176/nmc.38.805

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Fasudil hydrochloride is a new type of intracellular calcium antagonist, different from the calcium entry blockers that are commonly employed for clinical use. Since September 1995, the combination of fasudil hydrochloride and ozagrel sodium, an inhibitor of thromboxane A(2) synthesis, has been used to treat 60 patients at risk of cerebral vasospasm after aneurysmal subarachnoid hemorrhage. The effectiveness of this combination therapy was investigated by comparison with the outcome of 57 patients previously treated with only ozagrel sodium, The combination therapy was significantly more effective (p < 0.01) in reducing the incidence of low density areas on computed tomography scans, and reduced, but not significantly, the occurrence of symptomatic vasospasm, The combination therapy of fasudil hydrochloride and ozagrel sodium has superior effectiveness over only ozagrel sodium in treating patients at risk of vasospasm after aneurysmal subarachnoid hemorrhage.

引用

页码：805 / 810

页数：6

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