Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion

被引：71

作者：

Colombo, MP

Mantovani, A

机构：

[1] Ist Nazl Tumori, Immunotherapy & Gene Therapy Unit, I-20133 Milan, Italy

[2] Univ Milan, Fac Med, Ist Clin Humanitas, Milan, Italy

来源：

CANCER RESEARCH | 2005年 / 65卷 / 20期

关键词：

D O I：

10.1158/0008-5472.CAN-05-2714

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor development and progression are strongly linked to inflammation and the presence of tumor-associated macrophages (TAMs). In murine tumors, antitumor activity can be achieved by targeting TAM recruitment, survival, activation, polarization, effector signaling, or extracellular matrix interactions. Thus, it may be possible to increase the efficacy of conventional cancer therapeutic strategies by targeting TAMs.

引用

收藏

页码：9113 / 9116

页数：4

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