Targeting myelomonocytic cells to revert inflammation-dependent cancer promotion

被引：71

作者：

Colombo, MP

Mantovani, A

机构：

[1] Ist Nazl Tumori, Immunotherapy & Gene Therapy Unit, I-20133 Milan, Italy

[2] Univ Milan, Fac Med, Ist Clin Humanitas, Milan, Italy

来源：

CANCER RESEARCH | 2005年 / 65卷 / 20期

关键词：

D O I：

10.1158/0008-5472.CAN-05-2714

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumor development and progression are strongly linked to inflammation and the presence of tumor-associated macrophages (TAMs). In murine tumors, antitumor activity can be achieved by targeting TAM recruitment, survival, activation, polarization, effector signaling, or extracellular matrix interactions. Thus, it may be possible to increase the efficacy of conventional cancer therapeutic strategies by targeting TAMs.

引用

收藏

页码：9113 / 9116

页数：4

相关论文

共 22 条

[11] Redirecting in vivo elicited tumor infiltrating macrophages and dendritic cells towards tumor rejection [J].

Guiducci, C ;

Vicari, AP ;

Sangaletti, S ;

Trinchieri, G ;

Colombo, MP .

CANCER RESEARCH, 2005, 65 (08) :3437-3446

[12] Cancer - Inflammation by remote control [J].

Mantovani, A .

NATURE, 2005, 435 (7043) :752-753

[13] Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes [J].

Mantovani, A ;

Sozzani, S ;

Locati, M ;

Allavena, P ;

Sica, A .

TRENDS IN IMMUNOLOGY, 2002, 23 (11) :549-555

[14] Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy [J].

Muller, AJ ;

DuHadaway, JB ;

Donover, PS ;

Sutanto-Ward, E ;

Prendergast, GC .

NATURE MEDICINE, 2005, 11 (03) :312-319

[15] IDO and tolerance to tumors [J].

Munn, DH ;

Mellor, AL .

TRENDS IN MOLECULAR MEDICINE, 2004, 10 (01) :15-18

[16] Endogenous inhibitors of angiogenesis [J].

Nyberg, P ;

Xie, L ;

Kalluri, R .

CANCER RESEARCH, 2005, 65 (10) :3967-3979

[17] A multigene assay to predict recurrence of tamoxifen-treated, node-negative breast cancer [J].

Paik, S ;

Shak, S ;

Tang, G ;

Kim, C ;

Baker, J ;

Cronin, M ;

Baehner, FL ;

Walker, MG ;

Watson, D ;

Park, T ;

Hiller, W ;

Fisher, ER ;

Wickerham, DL ;

Bryant, J ;

Wolmark, N .

NEW ENGLAND JOURNAL OF MEDICINE, 2004, 351 (27) :2817-2826

[18] NF-κB functions as a tumour promoter in inflammation-associated cancer [J].

Pikarsky, E ;

Porat, RM ;

Stein, I ;

Abramovitch, R ;

Amit, S ;

Kasem, S ;

Gutkovich-Pyest, E ;

Urieli-Shoval, S ;

Galun, E ;

Ben-Neriah, Y .

NATURE, 2004, 431 (7007) :461-466

[19] Tumour-educated macrophages promote tumour progression and metastasis [J].

Pollard, JW .

NATURE REVIEWS CANCER, 2004, 4 (01) :71-78

[20] Leukocyte, rather than tumor-produced SPARC, determines stroma and collagen type IV deposition in mammary carcinoma [J].

Sangaletti, S ;

Stoppacciaro, A ;

Guiducci, C ;

Torrisi, MR ;

Colombo, MP .

JOURNAL OF EXPERIMENTAL MEDICINE, 2003, 198 (10) :1475-1485