Drug-target network and polypharmacology studies of a Traditional Chinese Medicine for type II diabetes mellitus

被引：58

作者：

Gu, Jiangyong ^{[1
]}

Zhang, Hu ^{[1
,2
]}

Chen, Lirong ^{[1
]}

Xu, Shun ^{[2
]}

Yuan, Gu ^{[1
]}

Xu, Xiaojie ^{[1
]}

机构：

[1] Peking Univ, Beijing Natl Lab Mol Sci, State Key Lab Rare Earth Mat Chem & Applicat, Coll Chem & Mol Engn, Beijing 100871, Peoples R China

[2] Zhengzhou Univ, Dept Chem, Zhengzhou 450052, Peoples R China

来源：

COMPUTATIONAL BIOLOGY AND CHEMISTRY | 2011年 / 35卷 / 05期

关键词：

Type II diabetes; Network analysis; Virtual screening; Traditional Chinese Medicine; Drug-target network; Polypharmacology; CARDIOVASCULAR-DISEASE; DOCKING;

D O I：

10.1016/j.compbiolchem.2011.07.003

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Many Traditional Chinese Medicines (TCMs) are effective to relieve complicated diseases such as type II diabetes mellitus (T2DM). In this work, molecular docking and network analysis were employed to elucidate the action mechanism of a medical composition which had clinical efficacy for T2DM. We found that multiple active compounds contained in this medical composition would target multiple proteins related to T2DM and the biological network would be shifted. We predicted the key players in the medical composition and some of them have been reported in literature. Meanwhile, several compounds such as Rheidin A, Rheidin C, Sennoside C, procyanidin Cl and Dihydrobaicalin were notable although no one have reported their pharmacological activity against T2DM. The association between active compounds, target proteins and other diseases was also discussed. (c) 2011 Elsevier Ltd. All rights reserved.

引用

页码：293 / 297

页数：5

共 34 条

[1] Network biology:: Understanding the cell's functional organization [J].