Tissue distribution and kinetics of gadolinium and nephrogenic systemic fibrosis

被引：72

作者：

Abraham, Jerrold L. ^{[1
]}

Thakral, Charu ^{[1
]}

机构：

[1] Upstate Med Univ, SUNY Albany, Dept Pathol, Syracuse, NY 13210 USA

来源：

EUROPEAN JOURNAL OF RADIOLOGY | 2008年 / 66卷 / 02期

关键词：

gadolinium; transmetallation; biodistribution; toxicology; scanning electron microscopy; tissue microanalysis;

D O I：

10.1016/j.ejrad.2008.01.026

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Gadolinium (Gd) released from Gd-based MR contrast agents is the likely etiologic agent of nephrogenic systemic fibrosis (NSF). The biodistribution and kinetics of both chelated Gd and free Gd3+ are reviewed, including demonstrations of Gd in tissues of NSF patients. The purpose of this review is to consolidate the available information on distribution, metabolism, excretion and retention of Gd with particular emphasis on the possible mechanisms in the development of NSF. We also raise serious concern about the growing tissue burden of Gd with the release of Gd from its chelates and its yet unknown consequences. The development of NSF as well as potential long-term consequences of tissue Gd retention represent a part of the spectrum of Gd toxicity. (C) 2008 Elsevier Ireland Ltd. All rights reserved.

引用

页码：200 / 207

页数：8

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