Preparation of nanoparticles by continuous-flow microfluidics

被引：196

作者：

Jahn, Andreas ^{[1
,2
]}

Reiner, Joseph E. ^{[1
]}

Vreeland, Wyatt N. ^{[1
]}

DeVoe, Don L. ^{[1
,2
]}

Locascio, Laurie E. ^{[1
]}

Gaitan, Michael

机构：

[1] Natl Inst Stand & Technol, Gaithersburg, MD 20899 USA

[2] Univ Maryland, College Pk, MD 20742 USA

来源：

JOURNAL OF NANOPARTICLE RESEARCH | 2008年 / 10卷 / 06期

关键词：

nanoparticles; continuous flow microfluidics; particle formation; liposomes; emulsions; metal colloids; nanomanufacturing;

D O I：

10.1007/s11051-007-9340-5

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We review a variety of micro- and nanoparticle formulations produced with microfluidic methods. A diverse variety of approaches to generate microscale and nanoscale particles has been reported. Here we emphasize the use of microfluidics, specifically microfluidic systems that operate in a continuous flow mode, thereby allowing continuous generation of desired particle formulations. The generation of semiconductor quantum dots, metal colloids, emulsions, and liposomes is considered. To emphasize the potential benefits of the continuous-flow microfluidic methodology for nanoparticle generation, preliminary data on the size distribution of liposomes formed using the microfluidic approach is compared to the traditional bulk alcohol injection method.

引用

页码：925 / 934

页数：10

共 64 条

[1] The liposomal formulation of doxorubicin [J].