Microbiological transformations 41. Screening for novel fungal epoxide hydrolases

被引：21

作者：

Moussou, P ^{[1
]}

Archelas, A ^{[1
]}

Furstoss, R ^{[1
]}

机构：

[1] Univ Mediteranee, Fac Sci Luminy, Grp Biocatalyse & Chim Fine, CNRS,ERS 157, F-13288 Marseille 9, France

来源：

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC | 1998年 / 5卷 / 5-6期

关键词：

alkyl and aryl substituted epoxides; enantiopure epoxides; fungi; epoxide hydrolase; enantioselective hydrolysis;

D O I：

10.1016/S1381-1177(98)00007-1

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A search for new fungal epoxide hydrolases is described, which led to the selection of seven strains of interest. The biohydrolyses of various alkyl and aryl epoxides using whole cells of these seven strains are described. The enantio- and regio-selectivity observed proved to be variable depending upon the type of fungus and the substrate structure. However, a general trend was the preferential formation of the diol with (R) absolute configuration at the carbon atom bearing the bulkier substituent. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：447 / 458

页数：12

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