Major bleeding complications in a specialized anticoagulation service

被引：58

作者：

Fanikos, J

Grasso-Correnti, N

Shah, R

Kucher, N

Goldhaber, SZ ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Med, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Pharm, Boston, MA 02115 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2005年 / 96卷 / 04期

关键词：

D O I：

10.1016/j.amjcard.2005.03.104

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Major bleeding complications were investigated in 2,460 patients with 3,684 patient-years of warfarin exposure from 2000 to 2003. The most common indications for anticoagulation were atrial fibrillation (30%), venous thromboembolic disease (28%) and mechanical heart valve prosthesis (15%). Eleven patients had 12 nonfatal major bleeding complications, with no fatal bleeds during the study. The incidence of major bleeding complications was 0.12%/year; there were 0.32 bleeds/100 patient-years of coverage. Of the 12 bleeding events, 5 (42%) were intracranial hemorrhages. The average hospitalization cost per patient was $15,988, and the average length of hospitalization was 6.0 days. (c) 2005 Elsevier-Inc. All rights reserved.

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收藏

页码：595 / 598

页数：4

相关论文

共 18 条

[1] A multicomponent intervention to prevent major bleeding complications in older patients receiving warfarin - A randomized, controlled trial [J].

Beyth, RJ ;

Quinn, L ;

Landefeld, CS .

ANNALS OF INTERNAL MEDICINE, 2000, 133 (09) :687-695

[2] Hemorrhagic events during therapy with recombinant tissue plasminogen activator, heparin, and aspirin for unstable angina (Thrombolysis in myocardial ischemia, phase IIIB trial) [J].

Bovill, EG ;

Tracy, RP ;

Knatterud, GL ;

Stone, PH ;

Nasmith, J ;

Gore, JM ;

Thompson, BW ;

Tofler, GH ;

Kleiman, NS ;

Cannon, C ;

Braunwald, E .

AMERICAN JOURNAL OF CARDIOLOGY, 1997, 79 (04) :391-396

[3] OPTIMAL ORAL ANTICOAGULANT-THERAPY IN PATIENTS WITH MECHANICAL HEART-VALVES [J].

CANNEGIETER, SC ;

ROSENDAAL, FR ;

WINTZEN, AR ;

VANDERMEER, FJM ;

VANDENBROUCKE, JP ;

BRIET, E .

NEW ENGLAND JOURNAL OF MEDICINE, 1995, 333 (01) :11-17

[4] Comparison of an anticoagulation clinic with usual medical care -: Anticoagulation control, patient outcomes, and health care costs [J].

Chiquette, E ;

Amato, MG ;

Bussey, HI .

ARCHIVES OF INTERNAL MEDICINE, 1998, 158 (15) :1641-1647

[5]

CORTELAZZO S, 1993, THROMB HAEMOSTASIS, V69, P316

[6] RISK-FACTORS FOR COMPLICATIONS OF CHRONIC ANTICOAGULATION - A MULTICENTER STUDY [J].

FIHN, SD ;

MCDONELL, M ;

MARTIN, D ;

HENIKOFF, J ;

VERMES, D ;

KENT, D ;

WHITE, RH .

ANNALS OF INTERNAL MEDICINE, 1993, 118 (07) :511-520

[7]

GRASSOCORRENTI N, 2003, CRIT PATH CARDIOL, V1, P41

[8] Prospective study of the outcomes of ambulatory patients with excessive warfarin anticoagulation [J].

Hylck, EM ;

Chang, YC ;

Skates, SJ ;

Hughes, RA ;

Singer, DE .

ARCHIVES OF INTERNAL MEDICINE, 2000, 160 (11) :1612-1617

[9] Effect of intensity of oral anticoagulation on stroke severity and mortality in atrial fibrillation [J].

Hylek, EM ;

Go, AS ;

Chang, YC ;

Jensvold, NG ;

Henault, LE ;

Selby, JV ;

Singer, DE .

NEW ENGLAND JOURNAL OF MEDICINE, 2003, 349 (11) :1019-1026

[10] RISK-FACTORS FAR INTRACRANIAL HEMORRHAGE IN OUTPATIENTS TAKING WARFARIN [J].

HYLEK, EM ;

SINGER, DE .

ANNALS OF INTERNAL MEDICINE, 1994, 120 (11) :897-902